Genome-wide association studies of magnetic resonance imaging (MRI) of diastolic heart function shed light on the underlying molecular mechanisms and support a causal role of diastolic function for the development of heart failure.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Harvey, W. in Exercitatio Anatomica de Motu Cordis et Sanguinis in Animalibus (Project Gutenberg) https://onlinebooks.library.upenn.edu/webbin/gutbook/lookup?num=67065 (1628).
Zile, M. R. & Brutsaert, D. L. Circulation 105, 1503–1508 (2002).
Thanaj, M. et al. Nat. Cardiovasc. Res. https://doi.org/10.1038/s44161-022-00048-2 (2022).
Mountjoy, E. et al. Nat. Genet. 53, 1527–1533 (2021).
Arking, D. E. et al. Nat. Genet. 46, 826–836 (2014).
Vasan, R. S. et al. J. Am. Med. Assoc. 302, 168–178 (2009).
Brady, M. et al. Cardiovasc. Res. 60, 347–354 (2003).
Carubelli, V. et al. Eur. J. Heart Fail. 22, 1684–1693 (2020).
Eijgelsheim, M. et al. Hum. Mol. Genet. 19, 3885–3894 (2010).
Tadros, R. et al. Nat. Genet. 53, 128–134 (2021).
Hinson, J. T. et al. Science 349, 982–986 (2015).
Tseng, L. T. et al. J. Formos. Med. Assoc. 117, 471–479 (2018).
Jansen, H. J. et al. Circ. Arrhythm. Electrophysiol. 12, e006863 (2019).
Yengo, L. et al. Preprint at bioRxiv https://doi.org/10.1101/2022.01.07.475305 (2022).
Wu, Y. et al. J. Mol. Cell. Cardiol. 32, 2151–2162 (2000).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests
Rights and permissions
About this article
Cite this article
Smith, J.G., Gidlöf, O. Genetic insights into cardiac relaxation and filling. Nat Cardiovasc Res 1, 291–293 (2022). https://doi.org/10.1038/s44161-022-00052-6
Published:
Issue Date:
DOI: https://doi.org/10.1038/s44161-022-00052-6