Statins continue to make a difference and are here to stay. A new study provides further evidence that statins can function beyond inhibition of cholesterol synthesis by increasing the rate of macrophage efferocytosis, via a reduction in the ‘don’t eat me’ signal CD47, thereby decreasing the atherosclerotic plaque burden.
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Acknowledgements
C.G. acknowledges research support from the NIH-NHLBI (R01 HL153712-01), AHA (20SFRN35210252) and CZI (NFL-2020-218415).
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Eberhardt, N., Giannarelli, C. Statins boost the macrophage eat-me signal to keep atherosclerosis at bay. Nat Cardiovasc Res 1, 196–197 (2022). https://doi.org/10.1038/s44161-022-00038-4
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DOI: https://doi.org/10.1038/s44161-022-00038-4
