Nature evolves proteins by iterating through an untold number of mutations over time. Now, a method is reported to prepare and optimize synthetic polypeptides in an automated high-throughput fashion driven by artificial intelligence.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Chan, H. S. & Dill, K. A. J. Chem. Phys. 95, 3775 (1991).
Wu, G. et al. Nat. Synth. https://doi.org/10.1038/s44160-023-00294-7 (2023).
Wyrsta, M. D., Cogen, A. L. & Deming, T. J. J. Am. Chem. Soc. 123, 12919–12920 (2001).
Deming, T. J. Chem. Rev. 116, 786–808 (2016).
Gauthier, M. A., Gibson, M. I. & Klok, H. A. Angew. Chem. Int. Ed. 48, 48–58 (2008).
Panganiban, B. et al. Science 359, 1239–1243 (2018).
Tamasi, M. J. et al. Adv. Mater. 34, e2201809 (2022).
Judzewitsch, P. R., Nguyen, T. K., Shanmugam, S., Wong, E. H. H. & Boyer, C. Angew. Chem. Int. Ed. 57, 4559–4564 (2018).
Hilburg, S. L., Ruan, Z., Xu, T. & Alexander-Katz, A. Macromolecules 53, 9187–9199 (2020).
Ruan, Z. et al. Nature 615, 251–258 (2023).
Wu, G. et al. Chem. Commun. 55, 7860–7863 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Gormley, A.J. Searching for protein mimicry. Nat. Synth 2, 471–472 (2023). https://doi.org/10.1038/s44160-023-00302-w
Published:
Issue Date:
DOI: https://doi.org/10.1038/s44160-023-00302-w