Bicyclo[1.1.1]pentyl (BCP) fragments are typically made from heat- and air-sensitive propellane, which decreases their potential impact in drug discovery. Now, easily accessible BCP sulfonium salts that are storable at room temperature enable the synthesis of a diverse set of functionalized BCP fragments.
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Aïssa, C. Storage without strain. Nat. Synth 2, 478–480 (2023). https://doi.org/10.1038/s44160-023-00290-x
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DOI: https://doi.org/10.1038/s44160-023-00290-x
