Direct, stereocontrolled functionalization of ubiquitous C(sp3)–H bonds represents the most efficient route towards highly valuable molecules from feedstock chemicals. Now, diverse, enantioenriched, unnatural α-amino acids are obtained from readily available carboxylic acids in one step via iron-catalysed asymmetric nitrene transfer, overcoming the reactivity and selectivity challenges of intermolecular C–H amination.
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Trinh, T.A., Schomaker, J.M. Unnatural α-amino acid synthesis. Nat. Synth 2, 600–601 (2023). https://doi.org/10.1038/s44160-023-00278-7
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DOI: https://doi.org/10.1038/s44160-023-00278-7
