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Synthetic methodology

Triple coupling to make alkynes

Nature Synthesis volume 2, pages 391–392 (2023)Cite this article

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Alkynes are functional groups which feature in various materials and bioactive molecules; however, efficient divergent strategies for their synthesis are lacking. Now, a coupling reaction between gem-diborylalkanes, esters and an aryl triflimide enables their construction.

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Fig. 1: Synthesis of alkynes through coupling of carboxylic esters with gem-diborylalkanes.

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  1. Twitter: @AhmadMasarwa2

Authors and Affiliations

  1. Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel

    Nadim Eghbarieh & Ahmad Masarwa

  2. The Center for Nanoscience and Nanotechnology, The Hebrew University Jerusalem, Jerusalem, Israel

    Ahmad Masarwa

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  1. Nadim Eghbarieh
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  2. Ahmad Masarwa
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Correspondence to Ahmad Masarwa.

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The authors declare no competing interests.

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Eghbarieh, N., Masarwa, A. Triple coupling to make alkynes. Nat. Synth 2, 391–392 (2023). https://doi.org/10.1038/s44160-023-00257-y

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