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Kinetic resolution of planar chiral metallocenes

Nature Synthesis volume 2, pages 13–14 (2023)Cite this article

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A method for the kinetic resolution of diverse planar chiral multisubstituted metallocenes through Rh-catalysed asymmetric C–H arylation of pre-functionalized metallocenes is developed. This general strategy allows for the synthesis of planar chiral 1,2- and 1,3-disubstituted metallocenes bearing a wide range of functional groups.

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Fig. 1: Synthesis of planar chiral metallocenes.

References

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This is a summary of: Liu, C.-X. et al. Kinetic resolution of planar chiral metallocenes using Rh-catalysed enantioselective C–H arylation. Nat. Synth. https://doi.org/10.1038/s44160-022-00177-3 (2022).

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Kinetic resolution of planar chiral metallocenes. Nat. Synth 2, 13–14 (2023). https://doi.org/10.1038/s44160-022-00178-2

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