Controllable cleavage and conversion of strong C(sp3)–H bonds remains a challenging task in organic synthesis. Here, a reaction design combining hydrogen atom transfer and copper catalysis is developed which allows enantioselective alkene difunctionalization using aliphatic C–H bond activation.
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The author declares no competing interests.
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Gong, L. Radical catalysis breaks and makes bonds. Nat. Synth 1, 915–916 (2022). https://doi.org/10.1038/s44160-022-00174-6