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Active sites in the right places

Bifunctional catalysts containing metal and acid sites are used industrially in alkane hydroconversion. Now, the nanoscale spatial separation of the two active sites is shown to promote hydroisomerization and inspires design principles for this type of catalyst.

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Fig. 1: The impact of metal–acid catalytic site intimacy on the selectivity of C7 isomers in the hydroisomerization of n-heptane.


  1. Zhou, W. et al. Chem. Soc. Rev. 48, 3193–3228 (2019).

    Article  CAS  PubMed  Google Scholar 

  2. Wu, S.-M., Yang, X.-Y. & Janiak, C. Angew. Chem. Int. Ed. 58, 12340–12354 (2019).

    Article  CAS  Google Scholar 

  3. Zhang, J. et al. Nat. Catal. 1, 540–546 (2018).

    Article  CAS  Google Scholar 

  4. Wu, J. et al. Chem. Commun. 56, 6297–6300 (2020).

    Article  CAS  Google Scholar 

  5. Liu, L. & Corma, A. Chem. Rev. 118, 4981–5079 (2018).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Cheng, K. et al. Angew. Chem. Int. Ed. 59, 3592–3600 (2020).

    Article  CAS  Google Scholar 

  7. Weisz, P. B. & Swegler, E. W. Science 126, 31–32 (1957).

    Article  CAS  PubMed  Google Scholar 

  8. Cheng, K. et al. Science 377, 204–208 (2022).

    Article  CAS  PubMed  Google Scholar 

  9. Michels, N.-L., Mitchell, S. & Pérez-Ramírez, J. ACS Catal. 4, 2409–2417 (2014).

    Article  CAS  Google Scholar 

  10. Medford, A. J. et al. J. Catal. 328, 36–42 (2015).

    Article  CAS  Google Scholar 

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Correspondence to Xiao-Yu Yang.

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Wu, SM., Čejka, J. & Yang, XY. Active sites in the right places. Nat. Synth 1, 757–758 (2022).

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