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β-Elimination rules for Pd

β-Hydride and β-heteroatom eliminations are competitive processes in many Pd-catalysed reactions but general strategies for controlling this selectivity have not been established. Now, a mechanistic study of Pd-alkyl complexes demonstrates that the choice of phosphine ligands and leaving groups controls selectivity.

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Fig. 1: The effects of β-migrating groups and ligands on competing β-heteroatom (β-X) and β-hydride (β-H) eliminations.


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Correspondence to Ryan A. Altman.

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Yang, MH., Altman, R.A. β-Elimination rules for Pd. Nat. Synth 1, 753–754 (2022).

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