β-Hydride and β-heteroatom eliminations are competitive processes in many Pd-catalysed reactions but general strategies for controlling this selectivity have not been established. Now, a mechanistic study of Pd-alkyl complexes demonstrates that the choice of phosphine ligands and leaving groups controls selectivity.
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The authors declare no competing interests.
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Yang, MH., Altman, R.A. β-Elimination rules for Pd. Nat. Synth 1, 753–754 (2022). https://doi.org/10.1038/s44160-022-00144-y