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Redesigning CO2 fixation

Nature has evolved several biosynthetic CO2 fixation pathways for the conversion of CO2 into multi-carbon molecules. Now, a synthetic acetyl-CoA bi-cycle is reported that offers increased carbon efficiency by rewiring carbon fixation and non-oxidative glycolysis with implications for industrial gas fermentation.

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Fig. 1: Acetyl-CoA biosynthetic pathways from CO2, with thermodynamic and enzymatic cost analysis.

protein images in dotted circles in panels a and b were created with; panels c and d were reproduced from ref. 8, Springer Nature Ltd.


  1. Lüthi, D. et al. Nature 453, 379–382 (2008).

    Article  Google Scholar 

  2. Scown, C. D. & Keasling, J. D. Nat. Biotechnol. 40, 304–307 (2022).

    Article  CAS  Google Scholar 

  3. Preiner, M. et al. Nat. Ecol. Evol. 4, 534–542 (2020).

    Article  Google Scholar 

  4. Russell, M. J. & Martin, W. Trends Biochem. Sci. 29, 358–363 (2004).

    Article  CAS  Google Scholar 

  5. Bar-Even, A., Noor, E. & Milo, R. J. Exp. Bot. 63, 2325–2342 (2012).

    Article  CAS  Google Scholar 

  6. Claassens, N. J., Cotton, C. A. R., Kopljar, D. & Bar-Even, A. Nat. Catal. 2, 437–447 (2019).

    Article  CAS  Google Scholar 

  7. Takors, R. et al. Microb. Biotechnol. 11, 606–625 (2018).

    Article  CAS  Google Scholar 

  8. Wu, C. et al. Nat. Synth. (2022).

    Article  Google Scholar 

  9. Ragsdale, S. W. & Pierce, E. Biochim. Biophys. Acta 1784, 1873–1898 (2008).

    Article  CAS  Google Scholar 

  10. Fast, A. G., Schmidt, E. D., Jones, S. W. & Tracy, B. P. Curr. Opin. Biotechnol. 33, 60–72 (2015).

    Article  CAS  Google Scholar 

  11. Bogorad, I. W., Lin, T.-S. & Liao, J. C. Nature 502, 693–697 (2013).

    Article  CAS  Google Scholar 

  12. Song, Y. et al. Proc. Natl Acad. Sci. USA 117, 7516–7523 (2020).

    Article  CAS  Google Scholar 

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Correspondence to Michael Köpke.

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Competing interests

M.K. is an employee of LanzaTech, a for-profit company commercializing gas fermentation.

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Köpke, M. Redesigning CO2 fixation. Nat. Synth 1, 584–585 (2022).

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