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SYNTHETIC BIOLOGY

Redesigning CO2 fixation

Nature has evolved several biosynthetic CO2 fixation pathways for the conversion of CO2 into multi-carbon molecules. Now, a synthetic acetyl-CoA bi-cycle is reported that offers increased carbon efficiency by rewiring carbon fixation and non-oxidative glycolysis with implications for industrial gas fermentation.

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Fig. 1: Acetyl-CoA biosynthetic pathways from CO2, with thermodynamic and enzymatic cost analysis.

protein images in dotted circles in panels a and b were created with Biorender.com; panels c and d were reproduced from ref. 8, Springer Nature Ltd.

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Correspondence to Michael Köpke.

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Competing interests

M.K. is an employee of LanzaTech, a for-profit company commercializing gas fermentation.

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Köpke, M. Redesigning CO2 fixation. Nat. Synth 1, 584–585 (2022). https://doi.org/10.1038/s44160-022-00131-3

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  • DOI: https://doi.org/10.1038/s44160-022-00131-3

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