Aminoglycosides are an important class of potent antibiotics; however traditional synthetic approaches are lengthy and often rely on enzyme-based routes. Now, a formal enantioselective copper-catalysed hydroamination of benzene enables the total synthesis of the antibiotic (+)-ribostamycin in ten linear steps.
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Arriaga, D.K., Thomas, A.A. Antibiotics the easy way. Nat. Synth 1, 504–505 (2022). https://doi.org/10.1038/s44160-022-00093-6
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DOI: https://doi.org/10.1038/s44160-022-00093-6
