A method for the synthesis of sterically congested α-amino acids and peptides using amino acid Schiff bases and hydrocarbons is developed. A superior helix-stabilizing effect of highly congested unnatural α-amino acids is demonstrated by circular dichroism measurements of synthesized peptides.
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References
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This is a summary of: Tsuji, T. et al. α-Amino acid and peptide synthesis using catalytic cross-dehydrogenative coupling. Nat. Synth. https://doi.org/10.1038/s44160-022-00037-0 (2022).
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Synthesis of highly congested α-amino acids and peptides. Nat. Synth 1, 269–270 (2022). https://doi.org/10.1038/s44160-022-00031-6
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DOI: https://doi.org/10.1038/s44160-022-00031-6
