Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

A single-cell-resolution mathematical model of the CA1 human hippocampus

We present a computational method to generate a single-cell-resolution model of human brain regions starting from microscopy images. The developed method has been benchmarked to reconstruct the CA1 region of a right human hippocampus, including anatomical cell organization, connectivity, and network activity.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Model generation from microscopy images.


  1. Bjornsson, B. & Hernandez-Boussard, T. Digital twins for predictive oncology will be a paradigm shift for precision cancer care. Nat. Med. 27, 2065–2066 (2021). This paper reports how digital twins can be efficiently adopted in clinical oncology.

    Article  Google Scholar 

  2. DeKraker, J. et al. Hippocampal subfields revealed through unfolding and unsupervised clustering of laminar and morphological features in 3D BigBrain. Neuroimage. 206, 116328–116340 (2020). This paper reports the labeling of hippocampal subregions in images from the BigBrain dataset.

    Article  Google Scholar 

  3. Gandolfi, D. et al. A realistic morpho-anatomical connection strategy for modelling full-scale point-neuron microcircuits. Sci Rep. 12, 13864–13881 (2022). This paper reports the development of a model of mouse CA1 hippocampus.

    Article  Google Scholar 

  4. Tsodyks, M. V. & Markram, H. The neural code between neocortical pyramidal neurons depends on neurotransmitter release probability. Proc. Natl Acad. Sci. USA 94, 719–723 (1997). This paper describes the modeling of synapses with short plasticity dynamics.

    Article  Google Scholar 

  5. Wang, H. E. Delineating epileptogenic networks using brain imaging data and personalized modelling in drug resistant epilepsy. Sci Transl. Med 15, 680 (2023). This paper reports the prediction of surgical performance by a model based on The Virtual Brain.

    Article  Google Scholar 

Download references

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Gandolfi, D. et al. Full-scale scaffold model of the human hippocampus CA1 area. Nat. Comput. Sci. (2023).

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

A single-cell-resolution mathematical model of the CA1 human hippocampus. Nat Comput Sci 3, 196–197 (2023).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing