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A single-cell-resolution mathematical model of the CA1 human hippocampus

We present a computational method to generate a single-cell-resolution model of human brain regions starting from microscopy images. The developed method has been benchmarked to reconstruct the CA1 region of a right human hippocampus, including anatomical cell organization, connectivity, and network activity.

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Fig. 1: Model generation from microscopy images.

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This is a summary of: Gandolfi, D. et al. Full-scale scaffold model of the human hippocampus CA1 area. Nat. Comput. Sci. https://doi.org/10.1038/s43588-023-00417-2 (2023).

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A single-cell-resolution mathematical model of the CA1 human hippocampus. Nat Comput Sci 3, 196–197 (2023). https://doi.org/10.1038/s43588-023-00421-6

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  • DOI: https://doi.org/10.1038/s43588-023-00421-6

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