A combination of Bayesian inference, physics modeling, and Markov chain Monte Carlo sampling allows for accurate inference of biomolecule numbers and their photophysical state in cellular clusters.
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References
Aquino, G., Clausznitzer, D., Tollis, S. & Endres, R. G. Phys. Rev. E 83, 021914 (2011).
Endres, R. G. & Wingreen, N. S. Proc. Natl Acad. Sci. USA 103, 13040–13044 (2006).
Specht, C. G. et al. Neuron 79, 308–321 (2013).
Shepard Bryan, J. IV, Sgouralis, I. & Pressé, S. Nat. Comput. Sci. https://doi.org/10.1038/s43588-022-00197-1 (2022).
von Toussaint, U. Rev. Mod. Phys. 83, 943–999 (2011).
Ferguson, T. S. Ann. Stat. 1, 209–230 (1973).
Broderick, T., Jordan, M. I. & Pitman, J. Bayesian Anal. 7, 439–476 (2012).
Bishop, C. Pattern Recognition and Machine Learning (Springer, 2006).
Cranmer, K., Brehmer, J. & Louppe, G. Proc. Natl Acad. Sci. USA 117, 30055–30062 (2020).
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Masson, JB. Counting biomolecules with Bayesian inference. Nat Comput Sci 2, 74–75 (2022). https://doi.org/10.1038/s43588-022-00202-7
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DOI: https://doi.org/10.1038/s43588-022-00202-7