Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

FLUORESCENCE MICROSCOPY

Counting biomolecules with Bayesian inference

A combination of Bayesian inference, physics modeling, and Markov chain Monte Carlo sampling allows for accurate inference of biomolecule numbers and their photophysical state in cellular clusters.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: An illustrative example of the Bayesian approach and the model architecture.

References

  1. Aquino, G., Clausznitzer, D., Tollis, S. & Endres, R. G. Phys. Rev. E 83, 021914 (2011).

    Article  Google Scholar 

  2. Endres, R. G. & Wingreen, N. S. Proc. Natl Acad. Sci. USA 103, 13040–13044 (2006).

    Article  Google Scholar 

  3. Specht, C. G. et al. Neuron 79, 308–321 (2013).

    Article  Google Scholar 

  4. Shepard Bryan, J. IV, Sgouralis, I. & Pressé, S. Nat. Comput. Sci. https://doi.org/10.1038/s43588-022-00197-1 (2022).

  5. von Toussaint, U. Rev. Mod. Phys. 83, 943–999 (2011).

    Article  Google Scholar 

  6. Ferguson, T. S. Ann. Stat. 1, 209–230 (1973).

    Article  Google Scholar 

  7. Broderick, T., Jordan, M. I. & Pitman, J. Bayesian Anal. 7, 439–476 (2012).

    Article  MathSciNet  Google Scholar 

  8. Bishop, C. Pattern Recognition and Machine Learning (Springer, 2006).

  9. Cranmer, K., Brehmer, J. & Louppe, G. Proc. Natl Acad. Sci. USA 117, 30055–30062 (2020).

    Article  MathSciNet  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jean-Baptiste Masson.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Masson, JB. Counting biomolecules with Bayesian inference. Nat Comput Sci 2, 74–75 (2022). https://doi.org/10.1038/s43588-022-00202-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43588-022-00202-7

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing