Detection of molecular quantitative trait loci (QTL) facilitates mechanistic insights into disease-associated genetic variants. A new study describes BaseQTL, which exploits allele-specific expression to map molecular QTL from sequencing reads even without paired genotype data.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$99.00 per year
only $8.25 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Knowles, D. A. et al. Nat. Methods 14, 699–702 (2017).
Kumasaka, N., Knights, A. J. & Gaffney, D. J. Nat. Genet. 48, 206–213 (2016).
Vigorito, E. et al. Nat. Comput. Sci. https://doi.org/10.1038/s43588-021-00087-y (2021).
GTEx Consortium. Science 348, 648–660 (2015).
GTEx Consortium. Science 369, 1318–1330 (2020).
Strober, B. J. et al. Science 364, 1287–1290 (2019).
Kilpinen, H. et al. Science 342, 744–747 (2013).
Sun, W. Biometrics 68, 1–11 (2012).
Love, M. I., Huber, W. & Anders, S. Genome Biol. 15, 550 (2014).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing interests.
Rights and permissions
About this article
Cite this article
Gamazon, E.R. Detecting context-dependent gene regulation. Nat Comput Sci 1, 393–394 (2021). https://doi.org/10.1038/s43588-021-00092-1
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43588-021-00092-1