Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

GENOME INFORMATICS

Detecting context-dependent gene regulation

Detection of molecular quantitative trait loci (QTL) facilitates mechanistic insights into disease-associated genetic variants. A new study describes BaseQTL, which exploits allele-specific expression to map molecular QTL from sequencing reads even without paired genotype data.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Approaches to mapping regulatory variation.

References

  1. 1.

    Knowles, D. A. et al. Nat. Methods 14, 699–702 (2017).

    Article  Google Scholar 

  2. 2.

    Kumasaka, N., Knights, A. J. & Gaffney, D. J. Nat. Genet. 48, 206–213 (2016).

    Article  Google Scholar 

  3. 3.

    Vigorito, E. et al. Nat. Comput. Sci. https://doi.org/10.1038/s43588-021-00087-y (2021).

  4. 4.

    GTEx Consortium. Science 348, 648–660 (2015).

    Article  Google Scholar 

  5. 5.

    GTEx Consortium. Science 369, 1318–1330 (2020).

    Article  Google Scholar 

  6. 6.

    Strober, B. J. et al. Science 364, 1287–1290 (2019).

    Article  Google Scholar 

  7. 7.

    Kilpinen, H. et al. Science 342, 744–747 (2013).

    Article  Google Scholar 

  8. 8.

    Sun, W. Biometrics 68, 1–11 (2012).

    MathSciNet  Article  Google Scholar 

  9. 9.

    Love, M. I., Huber, W. & Anders, S. Genome Biol. 15, 550 (2014).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Eric R. Gamazon.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Gamazon, E.R. Detecting context-dependent gene regulation. Nat Comput Sci 1, 393–394 (2021). https://doi.org/10.1038/s43588-021-00092-1

Download citation

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing