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Detecting context-dependent gene regulation

Detection of molecular quantitative trait loci (QTL) facilitates mechanistic insights into disease-associated genetic variants. A new study describes BaseQTL, which exploits allele-specific expression to map molecular QTL from sequencing reads even without paired genotype data.

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Fig. 1: Approaches to mapping regulatory variation.


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Correspondence to Eric R. Gamazon.

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The author declares no competing interests.

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Gamazon, E.R. Detecting context-dependent gene regulation. Nat Comput Sci 1, 393–394 (2021).

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