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Tumor immunology

PRMT9 inhibition sparks immune responses in AML

Nature Cancer volume 5, pages 539–541 (2024)Cite this article

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Arginine methylation is crucial for tumor maintenance. PRMT9 levels are elevated in acute myeloid leukemia, and its inhibition eradicates leukemia by diminishing arginine methylation of proteins involved in DNA damage response and RNA translation. This activates the cGAS–STING pathway, which triggers immune responses directed against leukemia. Epigenetic targeting of DNA-damage-response mechanisms may bolster anti-tumor immunity.

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Fig. 1: Inhibition of PRMT9 enhances anti-tumor immunity.

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Authors and Affiliations

  1. San Raffaele Telethon Institute for Gene Therapy (SR-TIGET), IRCCS San Raffaele Scientific Institute, Unit of Senescence in Stem Cell Aging, Differentiation and Cancer, Milano, Italy

    Antonella Santoro & Raffaella Di Micco

  2. University School for Advanced Studies IUSS, Pavia, Italy

    Raffaella Di Micco

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  1. Antonella Santoro
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  2. Raffaella Di Micco
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Correspondence to Raffaella Di Micco.

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Santoro, A., Di Micco, R. PRMT9 inhibition sparks immune responses in AML. Nat Cancer 5, 539–541 (2024). https://doi.org/10.1038/s43018-024-00753-w

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