Identifying which patients will benefit most from immune checkpoint blockade (ICB) is an important clinical challenge. A study now finds that Vδ1+ γδ T cells are associated with better response to ICB in melanoma tumors with a lower neoantigen load and shows that some effector functions of PD-1+ Vδ1+ T cells are repressed after engagement of PD-1 by PD-L1.
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References
Davies, D. et al. Nat. Cancer https://doi.org/10.1038/s43018-023-00690-0 (2024).
Schumacher, T. N. & Schreiber, R. D. Science 348, 69–74 (2015).
Gentles, A. J. et al. Nat. Med. 21, 938–945 (2015).
Moore, O. S. Jr. & Foote, F. W. Jr. Cancer 2, 635–642 (1949).
Sireci, G. et al. Hum. Immunol. 58, 70–82 (1997).
Cerapio, J. P. et al. OncoImmunology 10, 1939518 (2021).
Wu, Y. et al. Sci. Transl. Med. 11, eaax9364 (2019).
Harmon, C. et al. Nat. Can. 4, 1122–1137 (2023).
de Vries, N. L. et al. Nature 613, 743–750 (2023).
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Widlund, H.R., Lynch, L. γδ T cells as unconventional targets of checkpoint blockade. Nat Cancer 5, 373–374 (2024). https://doi.org/10.1038/s43018-024-00735-y
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DOI: https://doi.org/10.1038/s43018-024-00735-y