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Cancer metabolism

Glutamine analogs for pancreatic cancer therapy

Nature Cancer volume 5, pages 2–4 (2024)Cite this article

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Inhibiting glutamine metabolism has thus far been clinically challenging. Two studies in preclinical mouse models now report that, in contrast to the failure of glutaminase inhibitors, broad suppression of glutamine metabolism with glutamine analogs delivered to tumors results in reduced pancreatic cancer growth, with targetable resistance mechanisms.

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Fig. 1: Broad inhibition of glutamine metabolism with DON or DRP-104.

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Authors and Affiliations

  1. Division of Endocrinology, Boston Children’s Hospital, Boston, MA, USA

    Nada Y. Kalaany

  2. Department of Pediatrics, Harvard Medical School, Boston, MA, USA

    Nada Y. Kalaany

  3. Broad Institute of MIT and Harvard, Cambridge, MA, USA

    Nada Y. Kalaany

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  1. Nada Y. Kalaany
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Correspondence to Nada Y. Kalaany.

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Kalaany, N.Y. Glutamine analogs for pancreatic cancer therapy. Nat Cancer 5, 2–4 (2024). https://doi.org/10.1038/s43018-023-00678-w

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