We developed a method for generating dendritic cell progenitors (DCPs) from hematopoietic stem and progenitor cells isolated from bone marrow or blood. When engineered to express IL-12 and FLT3L, these DCPs reprogram the tumor microenvironment and elicit anti-tumor immunity without the need for ex vivo antigen loading.
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This is a summary of: Ghasemi, A. et al. Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy. Nat. Cancer https://doi.org/10.1038/s43018-023-00668-y (2023).
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An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading. Nat Cancer 5, 224–225 (2024). https://doi.org/10.1038/s43018-023-00674-0
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DOI: https://doi.org/10.1038/s43018-023-00674-0
