Certain cancers disrupt metabolism, leading to the wasting syndrome known as cachexia. How tumor-induced mediators of cachexia induce changes in end organs is unclear. A study implicates the endothelium as an amplifier of tumor signals in fat, in which NOTCH1 promotes adipose tissue remodeling via retinoic acid, IL-33 and IGFBP3.
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T.A.Z. serves or has previously served on advisory boards and/or as a scientific advisory board member for PeleOS Technologies, LLC; Emmyon, Inc; Aveo; and Immuneering.
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Counts, B.R., Zimmers, T.A. Endothelium directs fat remodeling in cachexia. Nat Cancer 4, 1531–1533 (2023). https://doi.org/10.1038/s43018-023-00644-6
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DOI: https://doi.org/10.1038/s43018-023-00644-6