The advantage of genomic monitoring over cytogenetics for clinical assessment of leukemia is illustrated by a case of pediatric acute lymphoblastic leukemia in which a lesion underlying lethal end-stage myeloid disease could be detected by whole-genome sequencing years before the risk manifested cytogenetically.
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Harmon, L.M., Triche, T.J. Evolutionary genomic analysis for ALL. Nat Cancer 4, 1058–1059 (2023). https://doi.org/10.1038/s43018-023-00605-z
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DOI: https://doi.org/10.1038/s43018-023-00605-z
