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Cancer pathology

Shooting for multiplexed pathology with Orion

Nature Cancer volume 4, pages 930–932 (2023)Cite this article

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Pathological diagnosis relies on morphological assessment of tissue using histological staining and molecular phenotyping through immunostaining that must be performed on separate tissue sections. Orion is a newly reported methodology that facilitates multiplexed immunostaining with histological staining on the same slide.

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Fig. 1: A comparison of existing highly multiplexed immunostaining strategies to the Orion platform.

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Authors and Affiliations

  1. Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR, USA

    Ashley N. Anderson

  2. Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR, USA

    Summer L. Gibbs

  3. Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA

    Summer L. Gibbs

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  1. Ashley N. Anderson
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  2. Summer L. Gibbs
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Correspondence to Summer L. Gibbs.

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Anderson, A.N., Gibbs, S.L. Shooting for multiplexed pathology with Orion. Nat Cancer 4, 930–932 (2023). https://doi.org/10.1038/s43018-023-00590-3

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