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Cancer immunology

The two sides of the γδ T cell coin

Nature Cancer volume 4, pages 1056–1057 (2023)Cite this article

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Distinct subsets of γδ T cells that operate to either prevent or promote cancer progression have been characterized in mice. A study now indicates that human tumor-infiltrating γδ T cells also are more diverse than previously appreciated, consisting of functionally distinct subsets with tumor-promoting or -restricting functions.

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Fig. 1: Human tumor-infiltrating γδ T cells are heterogenous in phenotype and function.

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Authors and Affiliations

  1. Cancer Research UK Beatson Institute, Glasgow, UK

    Seth B. Coffelt & Toshiyasu Suzuki

  2. School of Cancer Sciences, University of Glasgow, Glasgow, UK

    Seth B. Coffelt & Toshiyasu Suzuki

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  1. Seth B. Coffelt
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  2. Toshiyasu Suzuki
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Correspondence to Seth B. Coffelt.

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The authors declare no competing interests.

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Coffelt, S.B., Suzuki, T. The two sides of the γδ T cell coin. Nat Cancer 4, 1056–1057 (2023). https://doi.org/10.1038/s43018-023-00587-y

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