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Cancer therapy

Exploiting liver metabolism for tissue-specific cancer targeting

Nature Cancer volume 4, pages 310–311 (2023)Cite this article

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Although targeting cancer cells on the basis of tissue-specific expression of key factors is an important strategy in precision oncology, few such therapies exist. Chemical screening now identifies YC-1 as a tissue-specific anti-cancer compound that is activated in the liver by the sulfotransferase enzyme SULT1A1.

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Fig. 1: Mechanism by which YC-1 specifically inhibits liver cancer cell growth.

References

  1. Deininger, M., Buchdunger, E. & Druker, B. J. Blood 105, 2640–2653 (2005).

    Article  CAS  PubMed  Google Scholar 

  2. Gordon, A. J. et al. JAMA Otolaryngol. Head Neck Surg. https://doi.org/10.1001/jamaoto.2022.3360 (2022).

    Article  PubMed  Google Scholar 

  3. Waks, A. G. & Winer, E. P. J. Am. Med. Assoc. 321, 288–300 (2019).

    Article  CAS  Google Scholar 

  4. Villanueva, A. N. Engl. J. Med. 380, 1450–1462 (2019).

    Article  CAS  PubMed  Google Scholar 

  5. Chang, M.-H. et al. Gastroenterology 151, 472–480.e1 (2016).

    Article  CAS  PubMed  Google Scholar 

  6. Petrick, J. L. & McGlynn, K. A. Curr. Epidemiol. Rep. 6, 104–111 (2019).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Shi, L. et al. Nat. Cancer https://doi.org/10.1038/s43018-023-00523-0 (2023).

    Article  PubMed  Google Scholar 

  8. Negishi, M. et al. Arch. Biochem. Biophys. 390, 149–157 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. Kumar, M., Gromiha, M. M. & Raghava, G. P. S. J. Mol. Recognit. 24, 303–313 (2011).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Children’s Research Institute, Departments of Pediatrics and Internal Medicine, Center for Regenerative Science and Medicine, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Zixi Wang & Hao Zhu

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  1. Zixi Wang
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  2. Hao Zhu
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Correspondence to Hao Zhu.

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The authors declare no competing interests.

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Wang, Z., Zhu, H. Exploiting liver metabolism for tissue-specific cancer targeting. Nat Cancer 4, 310–311 (2023). https://doi.org/10.1038/s43018-023-00530-1

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