A study of the immune microenvironment of estrogen receptor-positive (ER+) invasive ductal carcinoma (IDC) and invasive lobular carcinoma (ILC) identifies pro-tumor and anti-tumor macrophages as key players that can potentially influence disease outcome.
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References
Barroso-Sousa, R. & Metzger-Filho, O. Differences between invasive lobular and invasive ductal carcinoma of the breast: results and therapeutic implications. Ther. Avd. Med. Oncol. 8, 261–266 (2016). A review article that presents a summary of clinical practices for IDC and ILC, highlighting the need for subtype-specific therapeutic approaches.
Ciriello, G. et al. Comprehensive molecular portraits of invasive lobular breast cancer. Cell 163, 506–519 (2015). The first large-scale comprehensive study of the genomic and molecular features of ILC.
Onkar, S. S. et al. The great immune escape: understanding the divergent immune response in breast cancer subtypes. Cancer Discov 13, 23–40 (2022). A review article that presents an overview of the similarities and differences in the immune response for three clinically relevant subtypes of breast cancer.
Gatti-Mays, M. E. et al. If we build it, they will come: targeting the immune response to breast cancer. NPJ Breast Cancer 5, 37 (2019). A comprehensive review that gives a rationale for immunotherapeutic approaches for breast cancer and details potential future strategies.
Wagner, J. et al. A single cell atlas of the tumor and immune ecosystem of human breast cancer. Cell 177, 1330–1345 (2019). A study presenting high-dimensional, single-cell phenotypic data on the functional state of immune and tumor cells in clinically relevant subtypes of breast cancer.
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This is a summary of: Onkar, S. et al. Immune landscape in invasive ductal and lobular breast cancer reveals a divergent macrophage-driven microenvironment. Nat. Cancer https://doi.org/10.1038/s43018-023-00527-w (2023).
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Estrogen receptor-positive breast cancer subtypes show differential macrophage functions. Nat Cancer 4, 450–451 (2023). https://doi.org/10.1038/s43018-023-00528-9
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DOI: https://doi.org/10.1038/s43018-023-00528-9
