Somatic mutations in cancer genomes are caused by multiple mutational processes, each generating characteristic mutational signatures. Our systematic mutational signature analysis of single base substitutions and small insertions and deletions in pediatric cancers indicates that the contribution of signatures of homologous recombination repair defect is limited and identifies a leukemia-specific signature.
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References
Stratton, M. R., Campbell, P. J. & Futreal, P. A. The cancer genome. Nature 458, 719–724 (2009). This review article presents the principles of cancer genomes and insights into oncogenesis.
Alexandrov, L. B. et al. The repertoire of mutational signatures in human cancer. Nature 578, 94–101 (2020). This landmark paper characterized mutational signatures from 4,645 whole-genome sequences and 19,184 exome sequences that encompass most types of cancer, as part of the Pan-Cancer Analysis of Whole Genomes.
Gröbner, S. N. et al. The landscape of genomic alterations across childhood cancers. Nature 555, 321–327 (2018). This paper describes one of the largest pan-cancer genomic analyses of pediatric cancer, with information on patterns of genetic alterations and drug targets.
McLeod, C. et al. St. Jude Cloud: A pediatric cancer genomic data-sharing ecosystem. Cancer Discov. 11, 1082–1099 (2021). This resource article presents a pediatric cancer genomic data-sharing ecosystem for accessing, analyzing and visualizing genomic data from over 10,000 pediatric patients with cancer.
Ma, J., Setton, J., Lee, N. Y., Riaz, N. & Powell, S. N. The therapeutic significance of mutational signatures from DNA repair deficiency in cancer. Nat. Commun. 9, 3292 (2018). This review article presents the therapeutic implications of mutational signatures from DNA repair deficiency in cancer.
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This is a summary of: Thatikonda, V. et al. Comprehensive analysis of mutational signatures reveals distinct patterns and molecular processes across 27 pediatric cancers. Nat. Cancer https://doi.org/10.1038/s43018-022-00509-4 (2023).
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The repertoire of mutational signatures in childhood cancer. Nat Cancer 4, 161–162 (2023). https://doi.org/10.1038/s43018-022-00512-9
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DOI: https://doi.org/10.1038/s43018-022-00512-9
