Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of mortality worldwide. Integrative analysis of the genome, transcriptome and proteome of PDAC tissues, also known as proteogenomic analysis, provides insight into the biology of this cancer and is a resource for therapeutic discovery.
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References
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Cancer Genome Atlas Research Network. Integrated genomic characterization of pancreatic ductal adenocarcinoma. Cancer Cell 32, 185–203 (2017). This paper reports an analysis of PDAC with integrated genomics.
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Cao, L. et al. Proteogenomic characterization of pancreatic ductal adenocarcinoma. Cell 184, 5031–5052 (2021). This paper reports the proteogenomic analysis of PDAC by the Clinical Proteogenomic Tumor Analysis Consortium.
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This is a summary of: Hyeon, D. Y. et al. Proteogenomic landscape of human pancreatic ductal adenocarcinoma in an Asian population reveals tumor cell-enriched and immune-rich subtypes. Nat. Cancer https://doi.org/10.1038/s43018-022-00479-7 (2022).
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Proteogenomic analysis of human pancreatic ductal adenocarcinoma. Nat Cancer 4, 163–164 (2023). https://doi.org/10.1038/s43018-022-00478-8
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DOI: https://doi.org/10.1038/s43018-022-00478-8
