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Glioblastoma

Treating glioblastoma often makes a MES

Nature Cancer volume 3, pages 1446–1448 (2022)Cite this article

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Glioblastoma (GBM) brain tumor cells exhibit pronounced phenotypic plasticity, but exactly how this enables GBMs to inevitably resist standard treatment is not known. A new study uses multilevel molecular profiling of pre- and post-treatment human GBMs to shed light on treatment response with single-cell and spatial resolution.

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Fig. 1: Wild-type IDH GBM cells lie on an axis between a proneural and mesenchymal state.

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Authors and Affiliations

  1. Leeds Institute of Medical Research, St James’s University Hospital, University of Leeds, Leeds, UK

    Lucy F. Stead

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  1. Lucy F. Stead
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Correspondence to Lucy F. Stead.

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The author declares no competing interests.

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Stead, L.F. Treating glioblastoma often makes a MES. Nat Cancer 3, 1446–1448 (2022). https://doi.org/10.1038/s43018-022-00471-1

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