Structural variants (SVs), such as copy-number alterations, rearrangements and aneuploidies, are common somatic changes in cancer genomes and rich sources of driver oncogenes, but reconstructing these from sequencing data is a challenge. Two new studies shed light on the diversity and importance of the SV landscape in cancer.
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References
Dubois, F., Sidiropoulos, N., Weischenfeldt, J. & Beroukhim, R. Nat. Rev. Cancer https://doi.org/10.1038/s41568-022-00488-9 (2022).
Turner, K. M. et al. Nature 543, 122–125 (2017).
Wu, S. et al. Nature 575, 699–703 (2019).
Hadi, K. et al. Cell 183, 197–210.e32 (2020).
Cortes-Ciriano, I., Gulhan, D. C., Lee, J. J.-K., Melloni, G. E. M. & Park, P. J. Nat. Rev. Genet. 23, 298–314 (2022).
Li, Y. et al. Nature 578, 112–121 (2020).
Drews, R. M. Nature 606, 976–983 (2022).
Steele, C. D. et al. Nature 606, 984–991 (2022).
Dubois, F. P. B. et al. Nat. Cancer https://doi.org/10.1038/s43018-022-00403-z (2022).
Bao, L., Zhong, X., Yang, Y. & Yang, L. Nat. Cancer https://doi.org/10.1038/s43018-022-00404-y (2022).
Nathanson, D. A. et al. Science 343, 72–76 (2014).
Hung, K. et al. Nature 600, 731–736 (2021).
Shoshani, O. et al. Nature 591, 137–141 (2021).
Ly, P. et al. Nat. Genet. 51, 705–715 (2019).
Zhang, C.-Z. et al. Nature 522, 179–184 (2015).
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P.S.M. is a co-founder and Scientific Advisory Board member and has equity interest in Boundless Bio. V.B. is a co-founder, consultant and Scientific Advisory Board member and has equity interest in Boundless Bio and Abterra. P.S.M. is team lead of and V.B. is a member of the Cancer Grand Challenges eDyNAmiC team.
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Mischel, P.S., Bafna, V. Form follows function in cancer genomes. Nat Cancer 3, 905–906 (2022). https://doi.org/10.1038/s43018-022-00428-4
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DOI: https://doi.org/10.1038/s43018-022-00428-4