Mesenchymal-like and pluripotency-like programs coordinate the dissemination and long-lived dormancy of early breast cancer cells. The transcription factor ZFP281 controls these programs, preventing the acquisition of an epithelial-like proliferative phenotype and serving as a previously unrecognized barrier to metastasis.
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References
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This is a summary of: Aguirre-Ghiso, J. A. et al. ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung. Nat. Cancer https://doi.org/10.1038/s43018-022-00424-8 (2022).
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A dormancy mechanism limits metastasis of early spreading cancer cells. Nat Cancer 3, 1147–1148 (2022). https://doi.org/10.1038/s43018-022-00425-7
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DOI: https://doi.org/10.1038/s43018-022-00425-7
