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TUMOR MICROENVIRONMENT

There are gremlins in prostate cancer

Nature Cancer volume 3, pages 530–531 (2022)Cite this article

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The lethality of prostate cancer is driven by its progression to a castration-resistant state. A new study identifies gremlin 1 (GREM1) as an agonist of fibroblast growth factor receptor 1 (FGFR1) that drives such progression when androgen receptor (AR) signaling is low, nominating GREM1 as a therapeutic target for prostate cancer with low AR activity.

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Fig. 1: GREM1 activity in castration-resistant prostate cancer.

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Authors and Affiliations

  1. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center (SKCCC), Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Laura A. Sena, W. Nathaniel Brennen & John T. Isaacs

  2. Department of Urology, James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    W. Nathaniel Brennen & John T. Isaacs

  3. Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    W. Nathaniel Brennen & John T. Isaacs

  4. Department of Chemical and Biomolecular Engineering, The Whiting School of Engineering, Johns Hopkins University, Baltimore, MD, USA

    John T. Isaacs

Authors
  1. Laura A. Sena
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  2. W. Nathaniel Brennen
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  3. John T. Isaacs
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Correspondence to W. Nathaniel Brennen or John T. Isaacs.

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Sena, L.A., Brennen, W.N. & Isaacs, J.T. There are gremlins in prostate cancer. Nat Cancer 3, 530–531 (2022). https://doi.org/10.1038/s43018-022-00381-2

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