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A community approach to the cancer-variant-interpretation bottleneck

Nature Cancer volume 3, pages 522–525 (2022)Cite this article

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As guidelines, therapies and literature on cancer variants expand, the lack of consensus variant interpretations impedes clinical applications. CIViC is a public-domain, crowd-sourced and adaptable knowledgebase of evidence for the clinical interpretation of variants in cancer, designed to reduce barriers to knowledge sharing and alleviate the variant-interpretation bottleneck.

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Fig. 1: Evolution of CIViC user engagement.
Fig. 2: CIViC data model updates and curation activity.

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Author information

Author notes

  1. These authors contributed equally: Kilannin Krysiak, Arpad M. Danos.

Authors and Affiliations

  1. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA

    Kilannin Krysiak & Alex R. Marr

  2. McDonnell Genome Institute, Washington University School of Medicine, St. Louis, MO, USA

    Kilannin Krysiak, Arpad M. Danos, Susanna Kiwala, Joshua F. McMichael, Adam C. Coffman, Erica K. Barnell, Lana Sheta, Jason Saliba, Lynzey Kujan, Shahil Pema, Nicholas C. Spies, Kaitlin A. Clark, Benjamin J. Ainscough, Brian V. Li, Katie M. Campbell, Kelsy C. Cotto, Zachary L. Skidmore, Jason R. Walker, Obi L. Griffith & Malachi Griffith

  3. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO, USA

    Kilannin Krysiak, Obi L. Griffith & Malachi Griffith

  4. Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA

    Arpad M. Danos, Erica K. Barnell, Lana Sheta, Jason Saliba, Lynzey Kujan, Shahil Pema, Nicholas C. Spies, Kaitlin A. Clark, Brian V. Li, Katie M. Campbell, Kelsy C. Cotto, Zachary L. Skidmore, Obi L. Griffith & Malachi Griffith

  5. Canada’s Michael Smith Genome Sciences Centre, Vancouver, British Columbia, Canada

    Cameron J. Grisdale & Steven J. M. Jones

  6. School of Computer Science, University of Glasgow, Glasgow, UK

    Jake Lever

  7. Department of Medicine, Division of Medical Oncology, University Health Network, Toronto, Ontario, Canada

    Andreea Chiorean, Payal Jani & Yasser Salama

  8. Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany

    Damian T. Rieke & Mario Lamping

  9. Department of Experimental Therapeutics/Department of Hepatobiliary and Pancreatic Oncology, National Cancer Center Hospital East, Kashiwa, Japan

    Hideaki Takahashi

  10. Department of Translational Medical Oncology, National Center for Tumor Diseases Heidelberg and German Cancer Research Center, Heidelberg, Germany

    Peter Horak

  11. Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA

    Deborah I. Ritter

  12. Texas Children’s Cancer Center, Texas Children’s Hospital, Houston, Texas, USA

    Deborah I. Ritter

  13. Department of Computational Biology, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Xin Zhou & Jinghui Zhang

  14. Lassonde School of Engineering, York University, Toronto, Ontario, Canada

    Sean Delong

  15. Mayo Clinic Florida, Jacksonville, FL, USA

    Wan-Hsin Lin

  16. Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Panieh Terraf

  17. Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada

    Kirsten M. Farncombe

  18. Children’s Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA

    Jianling Ji & Gordana Raca

  19. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA

    Xiaonan Zhao, Aleksandar Milosavljevic & Ronak Y. Patel

  20. Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

    Xinjie Xu

  21. Department of Hematopathology and Molecular Diagnostics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Rashmi Kanagal-Shamanna

  22. International Kidney Cancer Coalition, Amsterdam, the Netherlands

    Rachel H. Giles

  23. Fred A. Litwin Family Centre in Genetic Medicine, Familial Cancer Clinic, Princess Margaret Cancer Centre, University Health Network, Department of Medicine, University of Toronto, Toronto, Ontario, Canada

    Raymond H. Kim

  24. University of Maryland School of Medicine, Baltimore, MD, USA

    Lynn M. Schriml

  25. The Steve and Cindy Rasmussen Institute for Genomic Medicine, Nationwide Children’s Hospital, Columbus, OH, USA

    Elaine R. Mardis & Alex H. Wagner

  26. Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA

    Elaine R. Mardis & Alex H. Wagner

  27. Department of Neurosurgery, The Ohio State University College of Medicine, Columbus, OH, USA

    Elaine R. Mardis

  28. Innovation Center for Biomedical Informatics, Georgetown University Medical Center, Washington, DC, USA

    Shruti Rao & Subha Madhavan

  29. Department of Biomedical Informatics, The Ohio State University College of Medicine, Columbus, OH, USA

    Alex H. Wagner

  30. Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA

    Obi L. Griffith & Malachi Griffith

Authors
  1. Kilannin Krysiak
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  33. Xiaonan Zhao
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  35. Rashmi Kanagal-Shamanna
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  36. Kelsy C. Cotto
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  41. Ronak Y. Patel
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  42. Rachel H. Giles
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  43. Raymond H. Kim
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  44. Lynn M. Schriml
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  47. Gordana Raca
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  48. Shruti Rao
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  49. Subha Madhavan
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  50. Alex H. Wagner
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  51. Obi L. Griffith
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  52. Malachi Griffith
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Corresponding authors

Correspondence to Kilannin Krysiak, Obi L. Griffith or Malachi Griffith.

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Competing interests

E.K.B. is an owner, employee and member of Geneoscopy, and an inventor of the intellectual property owned by Geneoscopy. K.M.C. is a shareholder in Geneoscopy and has received honoraria from PACT Pharma and Tango Therapeutics. D.T.R. provides consulting for Alacris Theranostics and has received honoraria from Bayer, Eli Lilly and Bristol Myers Squibb.

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Krysiak, K., Danos, A.M., Kiwala, S. et al. A community approach to the cancer-variant-interpretation bottleneck. Nat Cancer 3, 522–525 (2022). https://doi.org/10.1038/s43018-022-00379-w

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