Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

TUMOR IMMUNOLOGY

DePICting T cell–APC crosstalk in cancer

Nature Cancer volume 3, pages 265–267 (2022)Cite this article

Subjects

Cellular communication in the tumor microenvironment is crucial for T cell activation; however, the molecular features of the T cell–antigen-presenting cell interaction are still poorly understood. A new study utilizes RNA sequencing of physically interacting cells to reveal that PD-1+CXCL13+ helper T cells in tumors, primed by dendritic cells, are important for the response to immunotherapy.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Tht cells, identified by PIC-seq in human lung tumors, facilitate the immune response to anti-PD-1 immunotherapy.

References

  1. Korman, A. J., Peggs, K. S. & Allison, J. P. Adv. Immunol. 90, 297–339 (2006).

    Article  CAS  Google Scholar 

  2. El-Khoueiry, A. B. et al. Lancet 389, 2492–2502 (2017).

    Article  CAS  Google Scholar 

  3. Korman, A. J., Garrett-Thomson, S. C. & Lonberg, N. Nat. Rev. Drug Discov. https://doi.org/10.1038/s41573-021-00345-8 (2021).

    Article  PubMed  Google Scholar 

  4. Cohen, M. et al. Nat. Cancer https://doi.org/10.1038/s43018-022-00338-5 (2022).

    Article  PubMed  Google Scholar 

  5. Giladi, A. et al. Nat. Biotechnol. 38, 629–637 (2020).

    Article  CAS  Google Scholar 

  6. Guo, X. et al. Nat. Med. 24, 978–985 (2018).

    Article  CAS  Google Scholar 

  7. Maier, B. et al. Nature 580, 257–262 (2020).

    Article  CAS  Google Scholar 

  8. Leader, A. M. et al. Preprint at bioRxiv https://doi.org/10.1101/2020.07.16.207605 (2020).

  9. Lavin, Y. et al. Cell 169, 750–765.e17 (2017).

    Article  CAS  Google Scholar 

  10. Katzenelenbogen, Y. et al. Cell 182, 872–885.e19 (2020).

    Article  CAS  Google Scholar 

  11. Wherry, E. J. & Kurachi, M. Nat. Rev. Immunol. 15, 486–499 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Shanghai Immune Therapy Institute, Shanghai Jiaotong University School of Medicine-affiliated Renji Hospital, Shanghai, China

    Ting Zhang & Chen Dong

  2. Institute of Immunology and School of Medicine, Tsinghua University, Beijing, China

    Chen Dong

Authors
  1. Ting Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chen Dong
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chen Dong.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, T., Dong, C. DePICting T cell–APC crosstalk in cancer. Nat Cancer 3, 265–267 (2022). https://doi.org/10.1038/s43018-022-00345-6

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s43018-022-00345-6

This article is cited by

Search

Advanced search

Quick links

Nature Briefing: Cancer

Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research, free to your inbox weekly.

Get what matters in cancer research, free to your inbox weekly. Sign up for Nature Briefing: Cancer