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CANCER BIOLOGY

A Wnt twist in FTO’s role in cancer progression

Nature Cancer volume 2, pages 579–580 (2021)Cite this article

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FTO, an m6A RNA demethylase, is known mainly as an oncoprotein in various cancer types. FTO is now shown to act as a cancer suppressor in a subset of epithelial tumors through an interplay between epithelial-to-mesenchymal transition and Wnt signaling.

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Fig. 1: FTO acts as a tumor suppressor in diverse epithelial cancers.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, CA, USA

    Albertas Navickas & Hani Goodarzi

  2. Department of Urology, University of California San Francisco, San Francisco, CA, USA

    Albertas Navickas & Hani Goodarzi

  3. Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA, USA

    Albertas Navickas & Hani Goodarzi

  4. Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, CA, USA

    Albertas Navickas & Hani Goodarzi

Authors
  1. Albertas Navickas
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  2. Hani Goodarzi
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Correspondence to Hani Goodarzi.

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The authors declare no competing interests.

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Navickas, A., Goodarzi, H. A Wnt twist in FTO’s role in cancer progression. Nat Cancer 2, 579–580 (2021). https://doi.org/10.1038/s43018-021-00224-6

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