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IMMUNOTHERAPY

Melanoma-reactive T cells take up residence

Nature Cancer volume 2, pages 253–255 (2021)Cite this article

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Shedding light on the mechanisms that underlie a durable response to immunotherapy, a recent study evaluating long-term survivors of melanoma treated with immunotherapy finds that tumor-associated T cell clonotypes are sustained over years and persist as expanded, cytokine IFN-γ–expressing resident memory T cells in the skin, with effector memory counterparts in the blood.

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Fig. 1: Clonally related, tumor-reactive T cells in patients with melanoma persist over time and in different compartments.

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Acknowledgements

A.-P.G. is funded by US National Institutes of Health K08 (5K08CA230164-03).

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Authors and Affiliations

  1. La Jolla Institute for Allergy & Immunology, La Jolla, CA, USA

    Anusha-Preethi Ganesan & Christian H. H. Ottensmeier

  2. Division of Pediatric Hematology Oncology, Rady Children’s Hospital, University of California San Diego, San Diego, CA, USA

    Anusha-Preethi Ganesan

  3. University of Liverpool, Institute of Systems, Molecular and Integrative Biology, Head and Neck Center, Liverpool, UK

    Christian H. H. Ottensmeier

  4. The Clatterbridge Cancer Center NHS Foundation Trust, Liverpool, UK

    Christian H. H. Ottensmeier

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  1. Anusha-Preethi Ganesan
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  2. Christian H. H. Ottensmeier
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Correspondence to Christian H. H. Ottensmeier.

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The authors declare no competing interests.

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Ganesan, AP., Ottensmeier, C.H.H. Melanoma-reactive T cells take up residence. Nat Cancer 2, 253–255 (2021). https://doi.org/10.1038/s43018-021-00189-6

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