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  • Cancer in Translation
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Microbiome genomics for cancer prediction

Nature Cancer volume 1, pages 379–381 (2020)Cite this article

Although cancer genomics is a powerful tool to understand cancer and develop diagnostic tools, the contribution of the microbiome in cancer diagnosis and clinical assessment is much less studied. Elinav, Greten and colleagues provide their respective views on how studying cancer metagenomes could facilitate identification, diagnosis and staging of different tumor types.

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Fig. 1: Microbial DNA signatures from tissue and blood to classify cancer.

References

  1. Viaud, S. et al. Science 342, 971–976 (2013).

    Article  CAS  Google Scholar 

  2. Sivan, A. et al. Science 350, 1084–1089 (2015).

    Article  CAS  Google Scholar 

  3. Gopalakrishnan, V. et al. Science 359, 97–103 (2018).

    Article  CAS  Google Scholar 

  4. Poore, G. D. et al. Nature 579, 567–574 (2020).

    Article  CAS  Google Scholar 

  5. Bullman, S. et al. Science 358, 1443–1448 (2017).

    Article  CAS  Google Scholar 

  6. Eisenhofer, R. et al. Trends Microbiol. 27, 105–117 (2019).

    Article  CAS  Google Scholar 

  7. Geller, L. T. et al. Science 357, 1156–1160 (2017).

    Article  CAS  Google Scholar 

  8. Zeevi, D. et al. Cell 163, 1079–1094 (2015).

    Article  CAS  Google Scholar 

  9. Nemet, I. et al. Cell 180, 862–877.e22 (2020).

    Article  CAS  Google Scholar 

  10. Riquelme, E. et al. Cell 178, 795–806.12 (2019).

    Article  CAS  Google Scholar 

  11. Ma, C. et al. Science 360, eaan5931 (2018).

    Article  Google Scholar 

  12. Human Microbiome Project Consortium. Nature 486, 207–214 (2012).

    Article  Google Scholar 

  13. Roy, S. & Trinchieri, G. Nat. Rev. Cancer 17, 271–285 (2017).

    Article  CAS  Google Scholar 

  14. Pagès, F. et al. Lancet 391, 2128–2139 (2018).

    Article  Google Scholar 

Download references

Acknowledgements

L.A. received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska‐Curie Grant Agreement No. 842203. E.E. is the incumbent of the Sir Marc and Lady Tania Feldmann Professorial Chair, a senior fellow at the Canadian Institute of Advanced Research (CIFAR) and an international scholar at the Bill & Melinda Gates Foundation and the Howard Hughes Medical Institute. T.F.G. is supported by the Intramural Research Program of the NIH, NCI (ZIA BC 011344).

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Authors and Affiliations

  1. Immunology Department, Weizmann Institute of Science, Rehovot, Israel

    Lorenz Adlung & Eran Elinav

  2. Cancer-Microbiome Division Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany

    Eran Elinav

  3. Thoracic and Gastrointestinal Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA

    Tim F. Greten & Firouzeh Korangy

Authors
  1. Lorenz Adlung
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  2. Eran Elinav
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  3. Tim F. Greten
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  4. Firouzeh Korangy
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Corresponding authors

Correspondence to Eran Elinav or Tim F. Greten.

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Competing interests

E.E. is a scientific consultant for DayTwo and BiomX.

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Adlung, L., Elinav, E., Greten, T.F. et al. Microbiome genomics for cancer prediction. Nat Cancer 1, 379–381 (2020). https://doi.org/10.1038/s43018-020-0059-x

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