Prospecting whole cancer genomes

A new suite of studies from the Pan Cancer Analysis of Whole Genomes (PCAWG) Consortium provides the most detailed resolution of cancer genomes to date, extending our knowledge of driver genes, mutational features, structural alterations and more. Kreisberg, Ideker, Mills and Meric-Bernstam discuss the foundational and translational insights gained from this project.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1.

    Hoadley, K. A. et al. Cell 173, 291–304.e6 (2018).

    CAS  Article  Google Scholar 

  2. 2.

    International Cancer Genome Consortium. et al. Nature 464, 993–998 (2010).

    Article  Google Scholar 

  3. 3.

    ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Nature 578, 82–93 (2020).

    Article  Google Scholar 

  4. 4.

    Zhang, W. et al. Nat. Genet. 50, 613–620 (2018).

    CAS  Article  Google Scholar 

  5. 5.

    Melton, C., Reuter, J. A., Spacek, D. V. & Snyder, M. Nat. Genet. 47, 710–716 (2015).

    CAS  Article  Google Scholar 

  6. 6.

    Hofree, M. et al. Nat. Commun. 7, 12096 (2016).

    CAS  Article  Google Scholar 

  7. 7.

    Reyna, M. A. et al. Nat. Commun. 11, 729 (2020).

    CAS  Article  Google Scholar 

  8. 8.

    Rheinbay, E. et al. Nature 578, 102–111 (2020).

    CAS  Article  Google Scholar 

  9. 9.

    Paczkowska, M. et al. Nat. Commun. 11, 735 (2020).

    CAS  Article  Google Scholar 

  10. 10.

    Shuai, S., Gallinger, S. & Stein, L. Nat. Commun. 11, 734 (2020).

    CAS  Article  Google Scholar 

  11. 11.

    Jiao, W. et al. Nat. Commun. 11, 728 (2020).

    CAS  Article  Google Scholar 

  12. 12.

    Yakneen, S. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-019-0360-3 (2020).

    CAS  Article  Google Scholar 

  13. 13.

    Gerstung, M. et al. Nature 578, 122–128 (2020).

    CAS  Article  Google Scholar 

  14. 14.

    PCAWG Transcriptome Core Group. Nature 578, 129–136 (2020).

    CAS  Article  Google Scholar 

  15. 15.

    Lui, G. Y. L., Grandori, C. & Kemp, C. J. J. Clin. Pathol. 71, 957–962 (2018).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding authors

Correspondence to Trey Ideker or Funda Meric-Bernstam or Gordon Mills.

Ethics declarations

Competing interests

G.B.M. is on the scientific advisory board or is a consultant for AstraZeneca, Chrysallis Biotechnology, ImmunoMET, Ionis, Lilly, PDX Pharmaceuticals, Signalchem Lifesciences, Symphogen and Tarveda; has stock, options or other financial interests in Catena Pharmaceuticals, ImmunoMet, SignalChem and Tarveda; has a licensed technology HRD assay to Myriad Genetics, and DSP patents with Nanostring; has research sponsored by Nanostring Center of Excellence and Ionis (provision of tool compounds only). F.M.-B is on the scientific advisory board or is a consultant for Immunomedics, Inflection Biosciences, Mersana Therapeutics, Puma Biotechnology, Seattle Genetics, Silverback Therapeutics, Spectrum Pharmaceuticals, Aduro BioTech, DebioPharm, eFFECTOR Therapeutics, F. Hoffman-La Roche, Genentech, IBM Watson, Jackson Laboratory, Kolon Life Science, OrigiMed, PACT Pharma, Parexel International, Pfizer, Samsung Bioepis, Seattle Genetics, Tyra Biosciences, Xencor and Zymeworks; has research sponsored by Aileron Therapeutics, AstraZeneca, Bayer Healthcare Pharmaceutical, Calithera Biosciences, Curis Inc., CytomX Therapeutics, Daiichi Sankyo, Debiopharm International, eFFECTOR Therapeutics, Genentech, Guardant Health, Millennium Pharmaceuticals, Novartis, Puma Biotechnology and Taiho Pharmaceutical; and receives honoraria from Chugai Biopharmaceuticals, Mayo Clinic, Rutgers Cancer Institute of New Jersey and UT Health San Antonio. T.I. is co-founder of and has an equity interest in Data4Cure; and has an equity interest in Ideaya BioSciences; the terms of this arrangement have been reviewed and approved by the University of California, San Diego in accordance with its conflict of interest policies.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Kreisberg, J.F., Ideker, T., Meric-Bernstam, F. et al. Prospecting whole cancer genomes. Nat Cancer 1, 273–275 (2020). https://doi.org/10.1038/s43018-020-0045-3

Download citation