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Mapping cell phenotypes in breast cancer

Nature Cancer volume 1, pages 156–157 (2020)Cite this article

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Tumor heterogeneity remains an obstacle to effective clinical management of breast cancer. Two new studies use high-dimensional imaging of single-cell protein expression in situ in clinical samples to link genomic alterations to multi-cellular features of the tumor microenvironment and reveal breast-cancer phenotypes associated with clinical outcome.

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Fig. 1: High dimensional imaging analysis of breast cancer.

References

  1. Jackson, H. W. et al. Nature https://doi.org/10.1038/s41586-019-1876-x (2020).

  2. Ali, H. R. et al. Nat. Cancer https://doi.org/10.1038/s43018-020-0026-6 (2020).

  3. Binnewies, M. et al. Nat. Med. 24, 541–550 (2018).

    Article  CAS  Google Scholar 

  4. Keren, L. et al. Cell 174, 1373–1387.e19 (2018).

    Article  CAS  Google Scholar 

  5. Hausser, J. et al. bioRxiv https://doi.org/10.1101/382291 (2018).

  6. Dvinge, H. et al. Nature 497, 378–382 (2013).

    Article  CAS  Google Scholar 

  7. Curtis, C. et al. Nature 486, 346–352 (2012).

    Article  CAS  Google Scholar 

  8. Pereira, B. et al. Nat. Commun. 7, 11479 (2016).

    Article  CAS  Google Scholar 

  9. Schapiro, D. et al. Nat. Methods 14, 873–876 (2017).

    Article  CAS  Google Scholar 

  10. Goltsev, Y. et al. Cell 174, 968–981.e15 (2018).

    Article  CAS  Google Scholar 

  11. Grün, D. et al. Cell Stem Cell 19, 266–277 (2016).

    Article  Google Scholar 

  12. Schürch, C. M. et al. bioRxiv https://doi.org/10.1101/743989 (2019).

  13. Arnol, D., Schapiro, D., Bodenmiller, B., Saez-Rodriguez, J. & Stegle, O. Cell Rep. 29, 202–211.e6 (2019).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pathology, Stanford University, Stanford, CA, USA

    Leeat Keren & Michael Angelo

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  1. Leeat Keren
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  2. Michael Angelo
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Correspondence to Michael Angelo.

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The authors declare no competing interests.

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Keren, L., Angelo, M. Mapping cell phenotypes in breast cancer. Nat Cancer 1, 156–157 (2020). https://doi.org/10.1038/s43018-020-0031-9

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