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  • Cancer in Translation
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A LIBRETTO to orchestrate targeted therapy

Nature Cancer volume 1, pages 1038–1040 (2020)Cite this article

Although RET alterations are relatively frequent across tumor types, specific targeting of RET in the clinic has been challenging. Ambrogio, Aggarwal and colleagues provide their views on how mechanistic studies have swiftly translated into powerful targeted therapies in two recent clinical studies that led to the FDA approval of selpercatinib for certain tumors in which RET is altered.

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Fig. 1: Timeline of key steps from the discovery of RET to the development of specific targeted therapy.

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Author information

Author notes

  1. These authors contributed equally: Melina E. Marmarelis, Roberto Chiarle.

Authors and Affiliations

  1. Division of Hematology-Oncology, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Melina E. Marmarelis & Charu Aggarwal

  2. Department of Pathology, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA

    Roberto Chiarle

  3. Department of Molecular Biotechnology and Health Sciences, University of Torino, Torino, Italy

    Roberto Chiarle & Chiara Ambrogio

Authors
  1. Melina E. Marmarelis
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  2. Roberto Chiarle
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  3. Chiara Ambrogio
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  4. Charu Aggarwal
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Corresponding authors

Correspondence to Chiara Ambrogio or Charu Aggarwal.

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The authors declare no competing interests.

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Marmarelis, M.E., Chiarle, R., Ambrogio, C. et al. A LIBRETTO to orchestrate targeted therapy. Nat Cancer 1, 1038–1040 (2020). https://doi.org/10.1038/s43018-020-00144-x

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