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IMMUNOTHERAPY

A nano-engager for iNKT cells in cancer

Nature Cancer volume 1, pages 1032–1034 (2020)Cite this article

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Invariant natural killer T cells (iNKT cells) are innate-like CD1d-restricted T cells that have NK cell–like properties and bear an invariant T cell receptor (iTCR). iNKT cells have shown potential for cancer immunotherapy. A study now shows that stabilization of the iTCR–CD1d complex via a single-chain bi-specific antibody stimulates iNKT cell–mediated anti-tumor immunity.

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Fig. 1: iNKT cell–related therapies.

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Authors and Affiliations

  1. Department of Medicine, Brigham & Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Mark A. Exley, Thomas Gensollen & Richard S. Blumberg

  2. University of Manchester, Manchester, UK

    Mark A. Exley

  3. Imvax, Philadelphia, PA, USA

    Mark A. Exley

  4. Agentus, Lexington, MA, USA

    Mark A. Exley

Authors
  1. Mark A. Exley
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  2. Thomas Gensollen
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  3. Richard S. Blumberg
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Correspondence to Mark A. Exley or Richard S. Blumberg.

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Competing interests

M.A.E. is employed by Imvax, a cancer vaccine–based company, and acts as consultant for Agentus, a company developing iNKT cell–based therapies.

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Exley, M.A., Gensollen, T. & Blumberg, R.S. A nano-engager for iNKT cells in cancer. Nat Cancer 1, 1032–1034 (2020). https://doi.org/10.1038/s43018-020-00138-9

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