CANCER IMMUNOTHERAPY

Optimizing CARs for ocular delivery

Effective methods for treating retinoblastoma while preserving vision are an unmet clinical need. Subretinal delivery of a hydrogel containing T cells that secrete the cytokine IL-15 and express a chimeric antigen receptor directed at the ganglioside protein GD2 completely controls retinoblastoma in immunocompromised mice, with no obvious damage to the surrounding retina.

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Fig. 1: Treatment of retinoblastoma with GD2 CAR T cells.

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Correspondence to Terry J. Fry.

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Nellan, A., Fry, T.J. Optimizing CARs for ocular delivery. Nat Cancer 1, 939–940 (2020). https://doi.org/10.1038/s43018-020-00127-y

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