Metastasis competence can be acquired early in tumorigenesis, although its underlying molecular intricacies remain unclear. A recent study provides key information about the function of L1CAM in conferring metastasis-initiation potential and chemoresistance in colorectal cancer by hijacking epithelial regenerative mechanisms.
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References
Lambert, A. W., Pattabiraman, D. R. & Weinberg, R. A. Cell 168, 670–691 (2017).
Pascual, G. et al. Nature 541, 41–45 (2017).
Ganesh, K. et al. Nat. Cancer https://doi.org/10.1038/s43018-019-0006-x (2020).
Blanpain, C. & Fuchs, E. Science 344, 1242281 (2014).
Batlle, E. & Clevers, H. Nat. Med. 23, 1124–1134 (2017).
Chen, J. et al. Nature 488, 522–526 (2012).
Ye, H. et al. Cell Stem Cell 19, 23–37 (2016).
Sánchez-Danés, A. et al. Nature 562, 434–438 (2018).
Valiente, M. et al. Cell 156, 1002–1016 (2014).
Er, E. E. et al. Nat. Cell Biol. 20, 966–978 (2018).
Barker, N. et al. Nature 449, 1003–1007 (2007).
Montgomery, R. K. et al. Proc. Natl Acad. Sci. USA 108, 179–184 (2011).
Barker, N. et al. Nature 457, 608–611 (2009).
Ayyaz, A. et al. Nature 569, 121–125 (2019).
Ladanyi, A. et al. Oncogene 37, 2285–2301 (2018).
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Pascual, G., Benitah, S.A. L1CAM links regeneration to metastasis. Nat Cancer 1, 22–24 (2020). https://doi.org/10.1038/s43018-019-0014-x
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DOI: https://doi.org/10.1038/s43018-019-0014-x