Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

BIOORTHOGONAL CATALYSIS

Exosomes for cell-targeted bioorthogonal catalysis

Transition metal-catalysed bioorthogonal reactions are severely hindered in biomedical applications, mainly due to a lack of target specificity. Now, research shows that a trojan exosome vesicle can deliver a palladium catalyst specifically to progenitor cells for bioorthogonal catalysis, allowing localized prodrug activation.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Fig. 1: Scheme of preparation and intracellular catalysis of Pd-loaded exosomes.

References

  1. 1.

    Sletten, E. M. & Bertozzi, C. R. Angew. Chem. Int. Ed. 48, 6974–6998 (2009).

    CAS  Article  Google Scholar 

  2. 2.

    Soldevila-Barreda, J. J. & Metzler-Nolte, N. Chem. Rev. 119, 829–869 (2019).

    CAS  Article  Google Scholar 

  3. 3.

    Ji, X. et al. Chem. Soc. Rev. 48, 1077–1094 (2019).

    CAS  Article  Google Scholar 

  4. 4.

    Wang, F., Zhang, Y., Du, Z., Ren, J. & Qu, X. Nat. Commun. 9, 1209 (2018).

    Article  Google Scholar 

  5. 5.

    Sancho-Albero, M. et al. Nat. Catal. https://doi.org/10.1038/s41929-019-0333-4 (2019).

  6. 6.

    Alvarez-Erviti, L. et al. Nat. Biotechnol. 29, 341–345 (2011).

    CAS  Article  Google Scholar 

  7. 7.

    Dong, H. et al. Anal. Chem. 90, 4507–4513 (2018).

    CAS  Article  Google Scholar 

  8. 8.

    Ngo, A. H., Bose, S. & Do, L. H. Chem. Eur. J. 24, 10584–10594 (2018).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Corresponding author

Correspondence to Xiaogang Qu.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Du, Z., Qu, X. Exosomes for cell-targeted bioorthogonal catalysis. Nat Catal 2, 837–838 (2019). https://doi.org/10.1038/s41929-019-0350-3

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing