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BIOORTHOGONAL CATALYSIS

Exosomes for cell-targeted bioorthogonal catalysis

Nature Catalysis volume 2, pages837–838(2019)Cite this article

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Transition metal-catalysed bioorthogonal reactions are severely hindered in biomedical applications, mainly due to a lack of target specificity. Now, research shows that a trojan exosome vesicle can deliver a palladium catalyst specifically to progenitor cells for bioorthogonal catalysis, allowing localized prodrug activation.

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Fig. 1: Scheme of preparation and intracellular catalysis of Pd-loaded exosomes.

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Affiliations

  1. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China

    Zhi Du & Xiaogang Qu

  2. University of Chinese Academy of Sciences, Beijing, China

    Zhi Du

Authors
  1. Zhi Du
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  2. Xiaogang Qu
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Correspondence to Xiaogang Qu.

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Du, Z., Qu, X. Exosomes for cell-targeted bioorthogonal catalysis. Nat Catal 2, 837–838 (2019). https://doi.org/10.1038/s41929-019-0350-3

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