Complex terpenes in one pot

The chemical synthesis of natural products, such as sesquiterpenes, is a daunting task due to their complexity and precise functionalization, and multiple synthetic and purification steps that reduce overall yields are usually required. Now, a highly efficient alternative approach using supramolecular chemistry has been proposed by Tiefenbacher and co-workers.

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Fig. 1: In-capsule synthetic approach.


  1. 1.

    Baran, P. S. J. Am. Chem. Soc. 140, 4751–4755 (2018).

    Article  CAS  PubMed  Google Scholar 

  2. 2.

    Clardy, J. & Walsh, C. Nature 432, 829–837 (2004).

    Article  CAS  PubMed  Google Scholar 

  3. 3.

    Christianson, D. W. Chem. Rev. 117, 11570–11648 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. 4.

    Magnard, J.-L. et al. Science 349, 81–83 (2015).

    Article  CAS  PubMed  Google Scholar 

  5. 5.

    Aizpurua-Olaizola, O. et al. J. Nat. Prod. 79, 324–331 (2016).

    Article  CAS  PubMed  Google Scholar 

  6. 6.

    Nicolaou, K. C. et al. Nature 367, 630–634 (1994).

    Article  CAS  PubMed  Google Scholar 

  7. 7.

    Zhang, Q., Rinkel, J., Goldfuss, B., Dickschat, J. S. & Tiefenbacher, K. Nat. Catal.–4 (2018).

  8. 8.

    Zhang, Q. & Tiefenbacher, K. Nat. Chem. 7, 197–202 (2015).

    Article  CAS  PubMed  Google Scholar 

  9. 9.

    Sobti, R. R. & Dev, S. Tetrahedron Lett. 8, 2893–2895 (1967).

    Article  Google Scholar 

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Correspondence to Dan Thomas Major.

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Major, D.T. Complex terpenes in one pot. Nat Catal 1, 567–568 (2018).

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