Abstract
Hypertension is a major cause of cardiovascular diseases. Several recent studies reported that pharmacists’ remote follow-up reduced hypertension patients’ blood pressure (BP). This meta-analysis aims to verify whether remote follow-up by pharmacists improves BP levels and reveal the factors that make the intervention effective. The search, conducted using PubMed/Medline, Embase, and Cochrane Library from June to July 2023, targeted articles published between October 1982 and June 2023, using terms including “pharmacist”, “hypertension”, and “randomized controlled trial (RCT)”. The inclusion criteria were: (a) RCTs involving hypertension patients with or without comorbidities, (b) pharmacists using remote communication tools to conduct follow-up encounter during the intervention period, (c) reporting systolic blood pressure (SBP) at baseline and during intervention. SBP was the primary outcome for the meta-analysis. Thirteen studies (3969 participants) were included in this meta-analysis. The mean difference of SBP between intervention group and control group was − 7.35 mmHg (P < 0.0001). Subgroup analyses showed the greater reduction of SBP in the “regularly scheduled follow-up cohort” (− 8.89 mmHg) compared with the “as needed follow-up cohort” (− 3.23 mmHg, P < 0.0001). The results revealed that remote follow-up by pharmacists reduced SBP levels in hypertension patients and scheduled remote follow-up may contribute to the effectiveness.
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Introduction
Hypertension is a major cause of strokes and cardiovascular diseases (CVD)1,2. Achieving blood pressure goals can dramatically reduce the risks of cardiovascular complications3,4,5. Still, control rates of BP among patients with hypertension remain low (23% for women and 18% for men in 2019)6. Suboptimal medication adherence is a well-recognized factor contributing to poor BP control in people with hypertension7. Medication event monitoring system8,9,10 and biochemical analysis using chromatography-tandem mass spectrometry11 are reported to be useful in detecting nonadherence and improving adherence in research. As biochemical analysis is an invasive method for patients, electronic monitoring is recognized as an easier method; however, neither may be feasible for use in real-world clinical settings. Some meta-analyses support the usefulness of self-monitoring of BP with additional support by professionals. Katrin Uhlig and colleagues revealed that BP self-monitoring plus additional support such as telemonitoring, counseling by healthcare professionals or nonprofessional healthcare coaches, and medication–behavioral management including medication management, physical exercise or dietary management improved BP levels12. Self-monitoring of BP worked best when combined with intensive interventions such as systematic medication titration and lifestyle counseling by healthcare professionals13. There are some recent reports of pharmacists performing interventions remotely including education and counseling for patients with hypertension. In these reports, follow-up was conducted using a variety of communication tools, including the telephone, web communications, and text messages according to the plan the providers established (e.g., frequency, interval, and timing of contact)14,15. A previous meta-analysis revealed that pharmacist interventions with home-based BP telemonitoring improved BP control in chronic kidney disease (CKD) patients16. Therefore, self-monitoring and additional support by healthcare practitioners are recognized as methods for improving BP in patients with hypertension. However, it remains unclear which is the most effective support for reducing BP levels. The current study expanded to include patients having hypertension and chronic disease other than CKD and interventions using communication tools in addition to telephones to compare telemonitoring tools and their influence on hypertension outcome during follow-ups. The aim of this meta-analysis was to determine whether remote follow-ups by pharmacists improve BP levels and identify factors that contribute to intervention effectiveness.
Results
Study selection
A search of the PubMed/Medline (n = 248), Embase (n = 553), and Cochran Library (n = 803) yielded 1604 relevant studies (Fig. 1) with 836 studies remained after removing duplicates. After excluding non-English records, conference reports, reviews, meta-analyses, research protocols, reports about non-RCT trials, and studies that did not meet the full eligibility criteria, 17 RCTs remained. After further excluding studies with inadequate data, 3969 participants from 13 RCTs were included in the present meta-analysis.
Study characteristics
Characteristics of 13 studies included in the meta-analysis were summarized in Table 1 in the Supplementary Materials. These 13 studies were conducted in seven countries: USA (n = 6)14,17,18,19,20,21, China (n = 2)22,23, India (n = 1)24, Nigeria (n = 1)15, Italy (n = 1)25, Australia (n = 1)26, Spain (n = 1)27. The mean subject age of seven studies was < 65 years14,15,17,18,20,23,25, and that of four studies was ≥ 65 years19,21,26,27. The mean age was not reported in two articles22,24. The intervention period ranged from 8 weeks to 12 months in the 13 included studies.
Effect of remote follow-up for BP control
The forest plot of comparison between intervention group (IG) and control group (CG) at the final point of the intervention period in 13 included studies is shown in Fig. 2. The mean difference in SBP between IG and CG was − 7.35 mmHg (95% Confidence Interval [CI] − 9.10 to − 5.59 mmHg, P < 0.0001), and there was a high degree of heterogeneity (χ2 = 44.09, df = 12, I2 = 73%).
Subgroup analysis
Regularity of follow-up
The mean differences in SBP between IG and CG were − 8.89 mmHg (95% CI − 10.11 to − 7.66 mmHg, P < 0.0001) and − 3.23 mmHg (95% CI − 5.72 to − 0.74 mmHg, P = 0.01) in the “regularly scheduled follow-up cohort (RFC)” and the “as needed follow-up cohort (AFC),” respectively (Fig. 3). In addition, there was a significant subgroup difference between RFC and AFC (P < 0.0001). Regarding heterogeneity, significant reductions were observed in both subgroups (P = 0.20, I2 = 28% in RFC, and P = 0.19, I2 = 37% in AFC) compared with the overall population (P < 0.0001, I2 = 73%).
Because there were two studies19,27 with large differences in baseline SBP, we repeated the analysis with these two studies removed. Even after excluding these studies, the SBP reduction effect by pharmacist remote follow-up interventions and subgroup differences between RFC and AFC remained significant (Supplementary Fig. 1).
Type of communication tools
The mean difference in SBP between IG and CG in the “telephone tool cohort (TTC)” and “other communication tool cohort (OCC)” were − 8.04 mmHg (95% CI − 9.85 to − 6.22 mmHg, P < 0.0001) and − 5.49 mmHg (95% CI − 10.32 to − 0.67 mmHg, P = 0.03), respectively (Fig. 4). There was no significant subgroup difference between TCC and OCC (P = 0.33). Regarding heterogeneity, the I2 of each subgroup was not significantly different from that of the overall group.
Communication with physician
The mean difference in SBP between IG and CG in the “physician communication cohort (PCC)” and “no physician communication cohort (NPC)” were − 6.56 mmHg (95% CI − 8.84 to − 4.28 mmHg, P < 0.0001) and − 8.96 mmHg (95% CI − 11.50 to − 6.42 mmHg, P < 0.0001), respectively (Fig. 5). No significant subgroup difference was observed between PCC and NPC (P = 0.17). Regarding heterogeneity, the I2 of each subgroup was not significantly different from that of the overall group.
Risk of bias assessment
The quality of included studies assessed by the Risk of Bias 2 (ROB2) tool is shown in Table 2. Because the number of excluded participants was not described in the study by Solomon and colleagues, it was rated high risk for missing the outcome data21. Due to insufficient randomization information and variability in baseline values, the study by Zaragoza-Fernandez et al.27 was rated high risk.
A funnel plot was created using mean differences in SBP at the final point of the intervention period in the 13 included studies (Fig. 6). Egger’s test for a regression intercept yielded a p value of 0.87, indicating no evidence of publication bias. For the three subgroup analyses, we considered the number of studies in each subgroup to be insufficient to statistically assess publication bias. Result of trim-and-fill analysis is also shown in Supplementary Table 1. There was no sign of publication bias (Mean differences of SBP and 95% CI were slightly different between using Review Manager and using Stata).
Sensitivity analysis
Results of sensitivity analyses are shown in Supplementary Table 2. The results were not substantively different under any conditions examined.
Discussion
Because of the recent COVID-19 pandemic, the attention to remote patient encounters and follow-ups has increased more than ever. The present study revealed that remote follow-up by pharmacists improved SBP levels compared with usual care in patients with hypertension. In the intervention group receiving pharmacists’ remote follow-up, regularly scheduled follow-up was found to be an important factor in the success of the intervention compared with as needed follow-up. A previous meta-analysis about pharmacist interventions in hypertension have revealed that interventions performed more often than once a month tended to be more effective than interventions performed less than once a month28. The same meta-analysis included trials outside of remote interventions, thus differing from the present study. However, our results were consistent with the previous study findings in that pharmacist interventions were useful for improving SBP among people with hypertension. Although our study did not evaluate the number of follow-ups performed, we saw that scheduling regular follow-up decreased SBP more effectively than scheduling follow-up as needed. Such a finding is novel and supports implementation of intentionally scheduling remote follow-ups by pharmacists for patients with hypertension. Regular follow-up with expected resource needs and devoted appointment time might benefit both patients and clinicians to achieve the treatment goals of chronic diseases such as hypertension.
In the present study, remote interventions by pharmacists using only telephone were not inferior to those using at least one other communication tool such as web communications or text messages. A network meta-analysis comparing the antihypertensive effects of interventions using various communication tools such as telephones, websites, Short Message Service (SMS) and smartphone- application software (apps) found that the combination of two or more tools was most effective, though the second most effective group used the telephone alone in lowering SBP29. The interventions in this meta-analysis were not delivered solely by pharmacists as in our study. In the present study, it was not possible to compare different types of communication tools because only two cohorts were formed due to small sample size, and one of the groups contained various types of communication tools used by pharmacists. But the result that remote interventions using telephone only were not inferior to those using other communication tools in lowering SBP was consistent with past study findings. In other words, pharmacists who do not have communication tools other than the telephone can provide effective interventions for hypertension patients if they follow-up regularly according to the planned schedule. At the same time, telephone calls can be inconvenient for some patients because they must be available at the time of the call. Although there might be a time lag from sending a message to checking and responding to the message, smartphone apps, emails, or text messages may be more convenient ways to communicate. Non-telephone tools were used for remote follow-up in three studies, but none of these examined age-related differences on intervention effectiveness. Therefore, it was not possible to assess statistically the impact of age-related differences in ability to use communication tools on intervention effectiveness except for telephone. Further studies are needed to evaluate the ability to use various communication tools by older patients, and when pharmacists follow up remotely with patients having hypertension, it would be best to use communication tools that fit the individual patient’s lifestyle and ability best.
Previous meta-analyses comparing pharmacist-led interventions and collaborative interventions by pharmacists and other healthcare professionals for hypertension patients showed that pharmacist-led interventions tended to be more effective. However, these intervention methods were not limited to remote follow-ups, as in the present study28. Thus, our study findings add to the existing evidence on pharmacist interventions and are consistent with previous study findings in which pharmacist-led interventions were effective regardless of collaboration with other professionals. However, the quality and frequency of pharmacists’ reports to physicians in PCC were not evaluated in our study. To enhance the effects of remote follow-up, the quality and timing of communication with physicians may be evaluated in future studies.
One of the limitations of the study is that the research outcome was limited to SBP as diastolic BP (DBP) values were not available in all included studies. The timing of SBP measurements differed among the included studies. The DBP outcome and timing of BP measures should be evaluated in future studies. We could not evaluate the impact of comorbidities and age on the intervention because the SBP of patients with each comorbidity was not available from the included RCTs. In AFC, follow-up was carried out as needed, so it is possible that not all subjects received remote follow-up by pharmacists during the study period. The impact of COVID-19 could not be assessed in the current study because study periods indicated by the included articles were prior to the beginning of the COVID-19 pandemic.
Conclusion
The present meta-analysis revealed that remote follow-up by pharmacists reduced SBP in patients with hypertension. In addition, regularly scheduled follow-up contributed to the success of remote follow-up compared with as needed follow-up. Higher quality studies are needed to identify the ideal combination of remote follow-up communication tools and methods that affect BP reduction.
Materials and methods
Data search and study selection
Based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guideline30 (PRISAMA2020 check list: Supplementary Table 3, PRISAMA2020 abstract check list: Supplementary Table 4), the search was conducted using PubMed/Medline, Embase, and Cochrane Library from June to July 2023. We searched for available articles published between October 1982 and June 2023. Searched terms included “pharmacist,” “hypertension,” and “randomized controlled trial” (Terms used for the search and the PubMed search details are shown in Supplementary Table 5). The search strategy is summarized in Fig. 1. Duplicate records, non-English records, conference reports, reviews, meta-analyses, research protocols, and reports about non-RCT trials were excluded from resulting records. Two reviewers independently assessed the articles for eligibility and data extraction and resolved disagreements by consensus. The inclusion criteria for the meta-analysis were as follows: (a) RCTs involving hypertension patients with or without coexisting chronic conditions (e.g., diabetes, CKD, CVD, stroke, human immunodeficiency virus [HIV] infection), (b) pharmacists using remote communication tool(s) to follow up with subjects during the intervention period, (c) studies reporting SBP at baseline and during the intervention period. Extracted data included study setting, characteristics of participants, intervention periods, types of remote communication tools used (e.g., telephone, text message, web communications, mail), number of study subjects and SBP. Finally, we excluded studies with inadequate values for Standard Deviation (SD) or 95% CI.
Outcome and data analysis
We selected SBP as the primary outcome of this meta-analysis because a reduction in SBP lowered the risk of cardiovascular events in the previous research. For instance, a 5 mmHg and 10 mmHg reduction in SBP decreased the risk of developing cardiovascular events by 10% and 20%, respectively3,5. The subjects receiving remote follow-up were categorized into the “IG”, while those receiving usual in-person follow-up categorized into the “CG”. We conducted the meta-analysis to elucidate the regularity of follow-up, the types of communication tools, and communication with physicians. We used the software Review Manager version 5.4 (The Cochrane Collaboration, London, UK). The mean difference, SD, and 95% CI were used to estimate effects. The calculator of Review Manager was used when it was necessary to calculate SD from the mean value of SBP and 95% CI. If the differences between two 95% CI values and the mean value differed by 0.1 from each other, the smaller value of 95% CI was adopted. The meta-analysis was undertaken using the random-effects model with the results presented in a forest plot. Statistical heterogeneity was evaluated by the I2 statistic. Since the present study was a literature review and meta-analysis of published data, no ethical or human subject protection evaluation was required.
Assessment of risk of publication bias
Two reviewers independently assessed the risk of bias with any disagreement resolved by consensus. Cochrane's ROB2 tool was used to assess the risk of bias31. This tool contains the following six assessment domains: (a) randomization process; (b) deviation from the intended interventions; (c) missing outcome data; (d) measurement of the outcome; (e) selection of the reported results; and (f) overall risk of bias. Each domain was ranked “low risk of bias,” “some concerns,” or “high risk of bias.” In addition, a funnel plot was constructed and Egger’s test32 and trim-and-fill analysis33 were conducted to detect the presence of potential publication bias in this random-effects meta-analysis model (Restricted Maximum Likelihood method) using statistical software Stata /MP version 18.0 (Stata Corp LLC, College Station, USA).
Sensitivity analysis
To assess data robustness, a sensitivity analyses was conducted by using Review manager. In the sensitivity analyses, we evaluated whether the results were affected by (1) excluding the study with the highest number of participants, (2) excluding the study in which the intervention reduced SBP the most, (3) excluding studies with high bias, (4) changing measurement time from the final point to the earlier time of intervention period (There were two studies in that SBP was measured at multiple times during the intervention period, and SBP was measured twice in both studies during the intervention period) and (5) changing from the random-effects model to the fixed-effect model.
Subgroup analysis
Remote follow-up success factor
We conducted three subgroup analyses to identify factors contributing to success of remote follow-up by pharmacists for BP improvement.
Regularity of follow-up
Thirteen studies were divided into two groups according to the following criteria. The studies having specific contact time or frequency of interventions were classified as “RFC”, while the studies without specific contact time or frequency of interventions were classified as “AFC”. RFC also contained the studies in which they conducted both regular and as needed follow-up.
Types of communication tools
Thirteen studies were divided into two groups according to the following criteria. The studies that used telephone only were classified as “TCC”, while the studies that used various communication tools were classified as “OCC” (Supplementary Table 1). OCC also contained the studies in which both telephone and other communication tools were used.
Communication with physician
Thirteen studies were divided into two groups according to the following criteria. In “PCC”, there were descriptions in the articles that pharmacists reported information from the patient encounters or their recommendations to physicians, while there was no description about them in the “NPC”.
Data availability
All data generated or analyzed during this study are included in this published article.
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Acknowledgements
We would like to thank Editage (https://www.editage.com/) for editing and reviewing this manuscript for English language.
Funding
This work was supported by SUGI Holdings Co., Ltd. The funder was involved in the study design, collection, analysis, interpretation of data, and the writing of this article.
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N.M. and T.M. contributed to the study conception and design and drafted the manuscript. N.M. and T.N. analyzed and interpreted the data. M.S., Y.A., S.S., J.K.L. and S.Y. contributed to the study design and reviewed the manuscript. T.M. supervised the execution of the study.
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The conflicts of interest from the past 3 years are as follows: NM, MS and YA are employees, and SS is vice president of Sugi Pharmacy Co., Ltd. SY received research support from Sugi Holdings Co., Ltd. TM received honoraria from WELCIA Holdings Co., Ltd. Other authors declare no conflict of interest.
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Matsumoto, N., Nakai, T., Sakakibara, M. et al. Remote follow-up by pharmacists for blood pressure control in patients with hypertension: a systematic review and a meta-analysis of randomized controlled trials. Sci Rep 14, 2535 (2024). https://doi.org/10.1038/s41598-024-52894-8
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DOI: https://doi.org/10.1038/s41598-024-52894-8
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