Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Retraction Note: MicroRNA-27a-3p Modulates the Wnt/β-Catenin Signaling Pathway to Promote Epithelial-Mesenchymal Transition in Oral Squamous Carcinoma Stem Cells by Targeting SFRP1

The Original Article was published on 20 April 2017

Retraction of: Scientific Reports, published online 20 April 2017

The authors have retracted this Article.

After publication they became aware that the oral cancer cell line had been contaminated with HeLa cells. In addition, there are irregularities in a number of figures, specifically:

  • Apparent overlap of the flow cytometry plots shown in Figure 1A and 1B which are for different cell lines

  • Duplication of blots between Figure 4A and Figure 4C

  • Duplication of blots between Figure 5B and Figure 5D

  • Duplication of blots between Figure 7B and Figure 7D

  • Duplication of parts of panels both within Figures 8 and 9 and between Figures 8 and 9 and parts of panels in figures in other articles1,2,3,4

All authors agree to this retraction


  1. Ba, S., Xuan, Y., Long, Z.-W., Chen, H.-Y. & Zheng, S.-S. MicroRNA-27a promotes the proliferation and invasiveness of colon cancer cells by targeting SFRP1 through the Wnt/β-catenin signaling pathway. Cell Physiol. Biochem. 42, 1920–1933 (2017).

    CAS  Article  Google Scholar 

  2. Xie, X. et al. MicroRNA-379 inhibits the proliferation, migration and invasion of human osteosarcoma cells by targetting EIF4G2. Biosci. Rep. 37, BSR20160542 (2017).

  3. Retracted article: He, Q. Y. et al. miR-106a-5p suppresses the proliferation, migration, and invasion of osteosarcoma cells by targeting HMGA2. DNA Cell Biol. 35, 506–520 (2016).

  4. Li, X. et al. MicroRNA-150 inhibits cell invasion and migration and is downregulated in human osteosarcoma. Cytogenet. Genome Res. 146, 124–135 (2015).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding authors

Correspondence to Bin Qiao or Alfred King-yin Lam.

Rights and permissions

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Qiao, B., He, BX., Cai, JH. et al. Retraction Note: MicroRNA-27a-3p Modulates the Wnt/β-Catenin Signaling Pathway to Promote Epithelial-Mesenchymal Transition in Oral Squamous Carcinoma Stem Cells by Targeting SFRP1. Sci Rep 10, 21317 (2020).

Download citation

  • Published:

  • DOI:


By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing