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# Imaging Dose, Cancer Risk and Cost Analysis in Image-guided Radiotherapy of Cancers

## Abstract

### Statistical analysis

Descriptive Statistics and Mann-Whitney Rank Sum Test were conducted using SigmaPlot suite (Version 12.0, Systat Software, San Jose, CA). A P-value less than or equal to 0.05 indicates a significant difference.

## Results

### Validation of Monte Carlo simulations

As shown in Fig. 1, Monte Carlo simulations of 4 imaging devices/protocols were compared with the ion chamber measurements in a 32-cm diameter CTDI phantom for (a) CT, (b) kVCBCT, (c) kVPI and (d) MVPI. The measured and simulated absolute doses (in cGy) were indicated with red and blue values for a variety of points located at the center, 3, 6, 9 and 12 o’clock positions, respectively. For clarity, only isodose lines of 20%, 40%, 60%, 80% and 100% of 4.5 cGy, 5.0 cGy, 2.0 cGy and 5.0 cGy were shown on (a) to (d), respectively. The relative differences of absolute dose between the Monte Carlo simulations and the ion chamber measurements ranged from 0.8% to 5.0% for CT, from 1.0% to 5.3% for kVCBCT, from 1.0% to 5.0% for kVPI, and from 0.3% to 2.9% for MVPI, respectively. Overall, the ion chamber measurements have confirmed the dose calculation accuracy of our Monte Carlo simulations of the imaging procedures to within 5.3%. Hence, these validated Monte Carlo models were employed in the subsequent population-based dose study in patient anatomy. Empirical functions were used to describe correlations between patient size and structural mean dose, whose parameters are listed in Table 2, where the empirical functions of kVCBCT for lungs and RBM were published in our previous work4,8.

### Patterns of image-guidance procedures

Figure 2 shows the statistics of various imaging procedures and the new patients receiving IGRT during the past four-and-half years at our institution. Overall, there has been a steady rise in the numbers of new patients and imaging procedures each year from 2009 to 2013, followed by a decrease in 2014. Compared to the previous year, the total number of imaging procedures increased by 52.1%, 26.6%, 14.7%, and 6.8%, respectively from 2010 to 2013. The decrease of imaging procedures in 2014 was primarily due to the decrease of new patients treated in the first months of 2014. KVCBCT, MVPI and kVPI accounted for 14.1%, 24.1 and 58.1% of all the 142,824 imaging procedures performed on 4,832 patients, respectively. The average CT, kVCBCT, MVPI and kVPI scans per patient were 1.1, 4.2, 7.1 and 17.2, respectively.

### Cumulative imaging doses to the brain, lungs and RBM

As shown in Fig. 3, since different image-guidance procedures were used in the head, thorax and pelvis regions, the dose depositions to the regional OARs were quite different. The majority of our patients received 15 cGy or less imaging doses to the lungs, yet the imaging doses to the brain and RBM ranged from 5 to 75 cGy for most patients. Among 5,384 organs being irradiated, the average (range) cumulative imaging doses to the brain, lungs and RBM were 38.0 (0.5–177.3), 18.8 (0.4–246.5), and 49.1 (0.4–274.4) cGy, respectively. Out of 4,832 patients, 63.8%, 88.7% and 61.9% of them received 50 cGy or less doses to the brain, lungs and RBM, respectively. Yet, 272 organs (19 brain, 19 lungs and 234 RBM volumes), which accounted for 5% of patients in this study, received 100 cGy or more doses with the maximum doses of 177.3, 246.5 and 274.4 cGy, respectively. Among these 272 organs with high doses, 6 brain and 5 lung volumes were from the patients younger than 20 years old. These high doses were found to be largely caused by the repetitive imaging procedures and non-personalized scan settings.

### The LAR of cancer incidence

Figure 4 depicts for both males and females, the correlations between the exposed age and averaged LAR of cancer incidence as a result of cumulative imaging doses to the brain, lungs and RBM, respectively. For both genders, the averaged LAR of incidence for brain and lung cancers decreased monotonically with age. However, the LAR of leukemia incidence displayed an unusual trend with a regular decrease in young groups followed by a “hump” in senior groups. The hump peaks around 65 years old for males due largely to the frequent kVCBCT scans in prostate IGRT, whereas it peaks around 45 years old for females due to the increased image-guidance in radiation treatments of pelvic lesions. Regardless of age, a statistically significant difference was observed for the LAR of both lung cancer and leukemia incidence between the males and females (p < 0.001), but was not present in the LAR of brain cancer incidence (p = 0.063). The difference between females and males for lung cancer LAR was largely due to the larger βS factor for the females in the BEIR VII model.

### Cost of imaging procedures in IGRT

Figure 5 shows the total cost of imaging procedures per patient for all the 4,832 patients from 2009 to 2014 with the 90th, 75th, median, 25th, and 10th percentiles indicated in the box plots and the outliers shown as solid symbols. Generally speaking, the median imaging cost experienced a gradual rise followed by a gentle decrease for each lesion site from 2009 to 2014. Specifically, the median imaging cost from 2009 to 2014 was $5028,$5028, $5256,$5636, $6548,$5788 in the head, $5028,$4976, $5180,$5180, $5370 and$5104 in the chest, and $6396,$6510, $7840,$8220, $6890 and$5636 in the pelvis, respectively. In any given year, the differences in the medians among the three sites are statistically significant (p = 0.016 for 2009, p < 0.001 from 2010 to 2013, and p = 0.025 for 2014). The median of the total imaging cost per patient in IGRT from 2009 to 2014 was $5180,$5180, $5256,$5465, $5484 and$5330, respectively.

## Discussion

In this study, organ-specific correlations between imaging dose and patient size were first established for various imaging procedures based on Monte Carlo simulations in patient anatomy. Subsequently, the established empirical functions (Table 2) coded with MATLAB were used to estimate organ doses when the OARs were irradiated by various imaging procedures in IGRT. In general, 64.4% of our 4,832 patients received dose of more than 10 cGy (equivalent to 100 mSv) from imaging procedures, 85.2%, 49.3% and 74.4% of which are in the brain, lungs and RBM groups, respectively. In addition, our results indicated that the cumulative imaging doses may not be considered negligible for a certain group of patients undergoing IGRT. For example, for children younger than 15 years, 5–10 abdominal CT scans or 2–3 head CT scans will result in a cumulative imaging dose of 5 cGy to the RBM or 6 cGy to the brain, respectively5. In our study, among the 59 children younger than 15 years, the average cumulative imaging doses to the brains and the RBMs were 64.4 cGy and 46.0 cGy, respectively, with the associated LAR 10 and 8 times higher than that from the CT scans5.

The cumulative imaging dose depended on the frequency of imaging acquisitions and the radiation dose of each procedure: the latter was directly related to the patient size and the scan settings. For example, using the default settings of CT, kVCBCT, kVPI and MVPI, the mean doses to the lungs were 0.5, 1.1, 0.7 and 2.9 cGy for an adult with a chest circumference of 120 cm, but were 0.8, 2.3, 1.4 and 3.7 cGy for a child with a chest circumference of 60 cm, respectively. The excessive dose to the child from the default settings was clinically unjustifiable and could be largely avoided by personalized imaging protocols25.

In the image-guided radiotherapy of cancers, there are the therapeutic doses used to kill the cancerous tissues as well as the imaging doses used for tumor localization. The ratio of the imaging dose to the therapeutic dose depends on the patient size, the prescription dose, the imaging modality, the frequency and the settings of the applied image-guidance procedures. In the studied patients, it was found that the average ratio (range) of the imaging dose to the therapeutic dose was 0.65% (0.01–7.59%), with about 0.2% of patients having a ratio larger than 5%. The benefit/risk of image-guidance should be carefully evaluated for this small group of patients.

Recently there have been a series of studies on the scatter and leakage doses from linear accelerators and the associated secondary cancer risk26,27,28,29,30,31. Vu Bezin et al. reported that the leakage doses from 6 MV photons were similar to those delivered during CT scans (0.2–6 cGy for a 70 Gy delivery at isocenter), and the low doses should not be neglected while estimating the secondary cancer risk30. In our study, 36.2%, 11.3% and 38.1% of patients received cumulative imaging doses of 50 cGy or more to the brains, lungs and RBM, respectively. The secondary cancer risk from the imaging doses may be comparable to that from the leakage dose in conformal and intensity-modulated radiation therapy26,27. Besides this preliminary study, long-term follow-up and prospective clinical trials will be much needed to confirm what kind of effect the cumulative doses from various radiological imaging procedures may have on the patients undergoing IGRT particularly children.

The imaging cost for a cancer patient consists of a fixed charge and a variable charge. While the fixed charge has been standardized per CMS billing codes, the variable charge depends on both the frequency and the type of image-guidance procedures. An optimized choice of the frequency and the procedure type could help reduce the imaging cost while maintaining a high quality for radiation treatment. Based on this study, the average imaging cost per patient was $6197,$6183, $6358,$6428, $6535 and$6092 from 2009 to 2014, respectively. An optimized and personalized application of the image-guidance procedures for each patient would help deliver a cost-effective health care in the radiotherapeutic management of cancers32,33. For example, we can personalize scan range for the individual patient, restrict the use of fluoroscopy, or choose alternative imaging modalities such as magnetic resonance imaging and ultrasound. Also, we should apply not only site-specific but also size-specific protocols to minimize radiation doses while maintaining acceptable imaging quality34.

It is important to recognize the importance of image-guidance in cancer radiotherapy as well as its potential risk1,35,36. On one hand, with image-guidance, the significant shrinkage of CTV-PTV margin will reduce not only the volume of healthy tissues near target exposed to higher doses of radiation but also the volume of normal tissues distal from target exposed to lower doses, hence resulting in a decrease in second cancers. On the other hand, as a result of smaller margins and better positioning with IGRT, higher therapeutic doses are more frequently delivered with modern advanced radiotherapy techniques such as SRS, SBRT and VMAT, which may increase the risk for second cancers in those patients if the tumoricidal doses were not delivered as planned due to intra-fraction organ motion or deformed target volume.

While the effects of high and acute doses of ionizing radiation are easily observed and understood in humans such as Japanese Atomic Bomb survivors, the effects of low-level radiation are very difficult to observe and highly controversial. This is because the baseline cancer rate is already very high and the risk of developing cancer fluctuates significantly with individual life style and environmental factors, obscuring the subtle effects of low-level radiation. This is especially true for the patients undergoing image-guided radiotherapy where a large lethal dose in the order of tens of Gy is intended for the tumor killing while a small imaging dose in the order of cGy to tens of cGy is used for tumor localization and alignment. However, besides the confirmed positive correlation between ionizing radiation and cancer risk in both children and radiation-monitored workers5,6, Mathews et al. have reported a dose-response relation in 680,000 children and adolescents with increased incidence of cancer due to exposure to low dose diagnostic CT scans at 4.5 mSv per scan37. Rampinelli et al. have recently demonstrated that the median cumulative radiation exposure from low dose CT screening over 10 years was 9.3 mSv for men and 13.0 mSv for women, respectively, with an non-negligible but acceptable cancer risk38. All of these studies have taken many years to finish. Hence, we expect that it would take a long-term investigation with collaborative efforts to determine the association of cancer with the imaging doses for a large patient population who undergoes IGRT of cancers.

While most of procedures are clinically justified by the benefit outweighing the potential risk, we should be prudent about the application of image-guidance in a small portion of patients who may receive dangerously high doses to some critical organs as a result of non-personalized scan settings and over-imaging. One end product of this retrospective study was the creation of an institutional ‘Big Data’ repository consisting of patient gender, age, size, treatment history, imaging procedures, shifts as well as organ dose depositions. Moving forward, we plan to track the organ doses for all the patients, particularly those with imaging doses higher than 100 cGy, considering the imaging doses as well as the scatter and leakage doses from the mega-voltage radiation treatments. A comprehensive understanding of organ doses would help the clinicians tailor radiotherapy for each of their patients.

## Conclusion

In conclusion, our results suggest that it is essential to evaluate the cumulative imaging doses to personalize image-guidance and radiation treatment for individual patient undergoing IGRT. Appropriate usage of image-guidance procedures is highly desired to maintain a cost-effective health care.

### Data availability

The corresponding author has full access to all the data in the study and final responsibility for the decision to submit for publication. The data in this study will be available from the corresponding author upon request.

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## Acknowledgements

The authors thank H. Liu (Department of Therapeutic Radiology, Yale-New Haven Hospital) and Y. Yan (Department of Radiation Oncology, University of Texas Southwestern Medical Center) for their assistance in this work. L.Z. was awarded a scholarship under the Sichuan University Scholarship Fund to pursue this research as a visiting scholar, working with J.D. at the Department of Therapeutic Radiology of Yale University from December 2013 to June 2015.

## Author information

Both L.Z. and J.D. contributed to literature search, study design, data collection, data analysis and manuscript writing, and collaborated with other authors. All authors reviewed the manuscript and made the decision to submit the manuscript for publication, and agreed to be accountable for the accuracy and integrity of the data and analyses.

Correspondence to Jun Deng.

## Ethics declarations

### Competing Interests

The authors declare no competing interests.

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