Abstract
The iodoform reaction has long been used as a qualitative test for acetyl and/or ethanol units in organic molecules. However, its synthetic applications are quite limited. Here, we describe a tuned iodoform reaction for oxidative demethylation reaction with I2 and t-BuOK in t-BuOH, in which in situ-generated t-BuOI serves as the chemoselective iodinating agent. This system enables one-step conversion of levulinic acid to succinic acid, a major four-carbon chemical feedstock. This oxidative demethylation is also applicable to other compounds containing an acetyl group/ethanol unit, affording the corresponding carboxylic acids in a selective manner.
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Introduction
Given the high cost, unsustainability, and environmental burden of petroleum, alternative processes for production of key chemical building blocks from non-petroleum-based resources such as natural gas, coal, or biomass, are of great interest1,2,3,4,5,6. For example, a fermentation route from edible biomass (glucose) to succinic acid 2 has recently been commercialized7. But, the use of non-edible lignocellulosic biomass as a source of valuable chemicals would be even more useful on the grounds of low cost and sustainability8,9. One of our group has established that simple treatment of lignocellulose with Lewis/Brønsted acid catalyst systems in water or methanol efficiently affords levulinic acid 1 or its methyl ester in a single step10,11,12,13,14,15. Therefore, a direct, simple chemical conversion of 1 to 2 (Fig. 1) is needed, because 2 is an important four-carbon feedstock for conversion to a range of useful chemicals, such as 1,4-butanediol, γ-butyrolactone, and 2-pyrrolidone, as well as being a raw material for bio-based polymers and green sustainable plastics16,17,18.
Thus, a straightforward and practical methodology for conversion of non-edible lignocellulose to succinic acid 2 via 1 should have important industrial applications. However, existing chemical methods for the conversion of 1 to 2 involve tedious multi-step synthesis19,20,21, harsh reaction conditions22,23, use of toxic heavy metals24, and/or low chemical yields25,26. For example, the gas-phase oxidation of 1 with vanadium catalyst affords a reasonable yield of 2, but requires high temperature (375 °C)22. Silica-coated magnetic nanoparticle-supported Ru(III) catalyzes the oxidation at somewhat lower temperature (150 °C), but 10 bar pressure of O2 is needed23. In 2015, a convenient method using aq. 30% H2O2 in acidic media was reported by Mascal, based on an unusual terminal Baeyer-Villiger oxidation (BVO)27,28 of 1 to afford 2 in 62% yield (Fig. 2)29. However, large amounts of acetic acid and 3-hydroxypropionic acid are formed concomitantly via normal BVO (ca. 6:4 selectivity). Thus, the development of a kinetically well-controlled transformation from 1 to 2 under mild conditions is still highly desirable. Herein, we report a new protocol for the direct conversion of 1 to 2 at room temperature in high chemical yield. Customization of the haloform reaction has enabled us to achieve one-step, regioselective oxidative demethylation of 1 under mild conditions. The procedure has also been successfully applied to a range of methyl ketones and secondary ethanol derivatives.
Results and Discussion
Synthesis of succinic acid from levulinic acid
The haloform reaction has traditionally been used as a chemical test to determine the presence of a methyl ketone. However, its synthetic use as for oxidative demethylation of methyl ketones is problematic because of side reactions such as internal α-CH oxidation/halogenation, aldol reaction, Favorskii rearrangement, etc. Indeed, only limited success has been reported to date, and the substrate generality and chemoselectivity of this reaction are therefore still unclear30,31,32,33,34. We thus commenced our studies with an examination of the “classical” iodoform reaction of 1. Exposure of 1 to a large excess of I2 and KOH in water at room temperature in air resulted in immediate precipitation of canary-yellow iodoform 3 (CHI3) and 2 was obtained in 36% yield, but significant side reactions affording 2-hydroxysuccinic acid 4 35 (34%) and fumaric acid 5 (3%) were also observed (Fig. 3). Decreasing the amounts of both reagents (I2 and KOH) significantly decreased the yield of 2, but failed to improve the chemoselectivity. The use of methyl levulinate 6 gave comparable results in terms of reactivity and selectivity. No further oxidation of 2 was observed under the reaction conditions, indicating that the 4 and 5 should be produced directly from starting material 1 or 6 (i.e., not via 2).
After extensive experimentation to find a better base/solvent system than HO–/water, we found that the combination of t-BuO– (base) and t-BuOH (solvent) improved the chemo/regioselectivity of the oxidative demethylation reaction (Table 1). This reaction system has a number of attractive features compared to the prototype iodoform conditions, as follows. Firstly, the t-BuOH (tertiary alcohol) is inherently resistant to the oxidation conditions, which represents an obvious advantage over other common alcohols, such as MeOH, EtOH, i-PrOH, etc 36. The use of t-amyl alcohol gave comparable results. Secondly, t-BuO– base would abstract a terminal α-methyl proton with kinetic preference over an internal α-proton. Thirdly, t-BuOI37,38,39,40 would be generated in situ, serving as the chemoselective iodinating agent41. These three factors would result in high selectivity, so that the internal CH2 group remains almost intact under these conditions. The reaction protocol in Table 1 involves i) pre-treatment with 3 equivalents (theoretical amount) of iodine and theoretical amount of t-BuOK in t-BuOH in order to form t-BuOI, followed by ii) addition of H2O, and then iii) a solution of 1 in t-BuOH, affording the desired product 2 with high selectivity. It is important to note that the pre-treatment is crucial for selective formation of 2. Direct addition of I2 to the mixture of 1 and t-BuOK in t-BuOH was unsatisfactory, resulting in a low yield (9%) of 2 and low selectivity: 2-methylsuccinic acid 7 (25%) and trace amount of glutaric acid 8 were formed, probably through Favorskii-type rearrangement via cyclopropanone intermediate 9 (Fig. 4)42.
We found that the amount of water and the concentrations of the reagents are critical factors affecting the reaction efficiency. Increased chemical yields of 2 were obtained by the use of 1–10 equivalents of water (entries 1–3). Slow addition (~10 min) of 1 to the solution of t-BuOH improved the reaction outcome (entries 4–10). The best result was obtained when 0.2 M of 1 in t-BuOH was used as a stock solution (entry 5), while 2.2 M solution of 1 gave a lower yield of 2 (entry 6). The optimized conditions could be scaled-up to 10 mmol (1.16 g) without any column purifications, although slight decrease in efficiency was observed (entry 7). It should be noted that the counter-cation of the base and the source of the halogen also played critical roles in determining the yield of this oxidative demethylation reaction. The use of t-BuONa instead of t-BuOK dramatically decreased the yield of 2 (entry 8), probably due to the relatively poor solubility of t-BuONa. We also found that other halogen sources, such as t-BuOCl and t-BuOBr, were ineffective, yielding only a small amount of 2 (for details, see Supporting Information, Figure S1).
Synthesis of succinic acid from cellulose
To elucidate the efficiency of modified iodoform reaction, direct one-pot synthesis of succinic acid 2 from cellulose 10 was investigated (Fig. 5). In(OTf)3–TsOH catalyzed refining of 10 yielding methyl levulinate 6, proceeded in high yield11,12. The reaction mixture was then hydrolyzed in water by remaining acids to give 1 quantitatively, which was followed by the demethylated under optimized reaction conditions to afford 2 in 81% yield (72%, three steps).
Scope and limitations
These reaction conditions were also applicable to various methyl ketones and secondary ethanol derivatives (Fig. 6). Simple methyl ketones such as 2-octanone 11 and sec-butyl methyl ketone 13 smoothly underwent oxidative demethylation reactions yielding corresponding carboxylic acids 12 and 14 in high yields, respectively. 4-Phenylbut-3-en-2-one 15 was efficiently converted to the corresponding carboxylic acid 16 in 95% yield. t-BuOI-mediated conditions were found to be suitable for a wide range of aromatic- and heteroaromatic systems. Not only electron deficient (17 and 19) but also electron rich (21 and 23) aryl methyl ketones serve as good substrates. In classical haloform reaction, electron rich aryl groups are troublesome substrates, but they were available in our system31,34. For these heterocycles, neither iodination of aromatic ring nor decarboxylation of products (22 and 24) were observed. Cyclopropyl methyl ketone 25 gave the desired product 26 in high yield and the cyclopropane ring remained intact. The stereochemistry of the starting materials (27 and 29) was almost completely retained in the products (28 and 30)43, implying high regioselectivity of the iodination step with these substrates. This system was also applicable to a secondary ethanol derivative 31, affording nonanoic acid 32 in 71% yield via oxidation/demethylation sequences. Similarly, N-acyl-N,O-acetal 33 undergoes demethylation 34 selectively, albeit in a moderate yield.
Conclusions
In summary, we have developed a simple, chemo-selective, cost-effective oxidative demethylation reaction of methyl ketones utilizing in situ-generated t-BuOI, which enables one-pot conversion of levulinic acid 1 to succinic acid 2 at room temperature. 2 is an important chemical feedstock, and our study offers the efficient chemical process to provide 2 from non-edible lignocellulose via 1. This system was also shown to be applicable to various substrates containing acetyl/ethanol units. Further studies to expand the scope of the reaction and to elucidation of the reaction mechanism with the help of theoretical and spectroscopic studies are in progress in our laboratory.
Method
General Information
IR spectra were recorded on a JASCO FT-IR 4700 spectrometer. 1H NMR and 13C NMR spectra were obtained on a Bruker AVANCE III HD spectrometer. Chemical shifts (δ) are reported in parts per million (ppm) downfield from internal Me4Si. Mass spectra (MS) were obtained on a Bruker micrOTOF-QIII spectrometer or an Agilent Model 5977B spectrometer. Preparative thin-layer chromatography (TLC) was carried out on pre-coated plates of silica gel (MERCK, silica gel F-254).
Substrate
3-Acetyl-1-pentyl-1H-indole (23) was prepared from commercially available 3-acetylindole in 2 steps according to the literature procedure44,45. A 4:1 mixture of endo- and exo-2-acetylnorbornane (27) was prepared from commercially available endo- and exo-2-acetylnorbornan-5-ene by hydrogenation with Pd/C and H2 according to the literature procedure:46 3-β-Methoxy-5-pregnen-20-one (29) was prepared from commercially available 3-β-hydroxy-5-pregnen-20-one according to the literature procedure47. N-(tert-Butoxycarbonyl)-2,2-dimethyl-4-(1-hydroxyethyl)oxazolidine (33) was prepared from corresponding aldehyde according to the literature procedure48.
Oxidative demethylation of levulinic acid (1) in water
To a stirred solution of KOH (315 mg, 5.6 mmol) and levulinic acid (1) (53 mg, 0.40 mmol) in water (10 mL) was added I2 (560 mg, 2.2 mmol) and the resulting yellow suspension was stirred at room temperature for 5 min. After treatment of HCl-acidified reaction mixture (pH ca. 1) with excess (≥1 mL) 30% aqueous H2O2, the mixture was washed several times with dichloromethane until the color of I2 and CHI3 faded. The aqueous phase was then concentrated in vacuo and extracted with acetone several times, which was concentrated in an aspiratory vacuum to give a mixture of dicarboxylic acids as a white powder. 1H NMR analysis (1,1,2,2-tetrachloroethane as an internal standard) showed the formation of succinic acid (2) (36%), 2-hydroxysuccinic acid (4) (34%), and fumaric acid (5) (4%) (Fig. 3).
Succinic acid (2)
colorless needles (recrystallized from acetone): IR (neat): ν = 3364–2159, 1680, 1410, 1306, 1196, 892, 800, 635, 581, 545 cm−1; 1H NMR (500 MHz, D2O): δ = 2.80 ppm (s, 4 H); 13C NMR (125 MHz, D2O): δ = 177.0, 28.7 ppm; MS (ESI (–)): m/z: 117 [(M-H)–]49.
Demethylation of levulinic acid (1) with I2 and t-BuOK in t-BuOH
To a stirred solution of t-BuOK (95 mg, 0.85 mmol) in distilled t-BuOH (1.4 mL) was added I2 (72 mg, 0.28 mmol) and the mixture was stirred at room temperature for a few minutes. After fading the color of I2, the beige suspension was added H2O (5.0 mg, 0.28 mmol) and then the solution of levulinic acid (1) (11 mg, 0.092 mmol) in dry t-BuOH (0.48 mL) dropwise during 10 min. After the reaction mixture was stirred at room temperature for additional 1 h, the mixture was concentrated in vacuo and dissolved in water. After treatment of HCl-acidified reaction mixture (pH ca. 1) with excess ( ≥ 1 mL) 30% aqueous H2O2, the mixture was washed several times with dichloromethane until the color of I2 and CHI3 faded. The aqueous phase was then concentrated in vacuo, and extracted with acetone several times, which was followed by the concentration in an aspiratory vacuum to give the mixture of dicarboxylic acids (10 mg) as a white powder. 1H NMR analysis (1,4-dioxane as an internal standard) showed the formation succinic acid (2) (83%), fumaric acid (5) (2%), and 2-hydroxysuccinic acid (4) (2%). Further recrystallization with acetone gave pure succinic acid (2) as colorless needles (9 mg, 83%) (Table 1, entry 5).
One-pot synthesis of succinic acid from cellulose
1st step (Caution! the reaction should be carried out behind the safety screen): According to the literature procedure11, cellulose (10) (428 mg, 2.64 mmol), indium(III) trifluoromethanesulfonate (22.4 mg 0.04 mmol), and p-toluenesulfonic acid (38 mg, 0.2 mmol) were suspended in methanol (20 mL) in a Schlenk flask under argon and vigorously stirred at 200 °C for 12 h, the reaction mixture was cooled to room temperature and concentrated under an aspiratory vacuum to give brown oil. 1H NMR analysis (1,4-dioxane as an internal standard) showed the formation of methyl levulinate (11) (89%), fumaric acid (5) (2%), and 2-hydroxysuccinic acid (4) (2%). Further recrystallization with acetone gave pure succinic acid (2) as colorless needles (Fig. 5).
2nd step: To the mixture was added H2O (10 mL) and stirred at 100 °C for 18 h until the disappearance of 11. After the mixture was cooled to room temperature, the mixture was concentrated in vacuo to give brown oil. 1H NMR analysis (1,4-dioxane as an internal standard) showed the formation of levulinic acid (1) (100%). The residue was dissolved in t-BuOH (10 mL) and transferred into a syringe in order to use for further transformations.
3rd step: To a stirred solution of t-BuOK (2.4 g, 21.2 mmol) in distilled t-BuOH (30 mL) in a Schlenk flask was added I2 (1.8 g, 7.05 mmol) and the mixture was stirred at room temperature for a few minutes. After fading the color of I2, the beige suspension was added H2O (127 mg, 7.05 mmol) and then the above solution of levulinic acid (1) (2.35 mmol) in dry t-BuOH (10 mL) dropwise during 10 min. After the reaction mixture was stirred at room temperature for additional 1 h, the mixture was concentrated in vacuo and dissolved in water. After treatment of HCl-acidified reaction mixture (pH ca. 1) with excess ( ≥ 2 mL) 30% aqueous H2O2, the mixture was washed several times with dichloromethane until the color of I2 and CHI3 faded. The aqueous phase was then concentrated in vacuo, and extracted with acetone several times. After the addition of acetic anhydride, the mixture was heated at 80 °C for 8 h. The mixture was cooled to room temperature and concentrated in vacuo to give succinic anhydride as a white powder (190 mg, 81%).
Succinic anhydride
1H NMR (500 MHz, DMSO-d 6): δ = 2.91 ppm (s, 4 H)50.
General procedure for demethylation of methyl ketones with I2 and t-BuOK in t-BuOH. A typical example: demethylation of 2-octanone (11)
To a stirred solution of t-BuOK (85 mg, 0.75 mmol) in distilled t-BuOH (1.4 mL) was added I2 (72 mg, 0.28 mmol) and the mixture was stirred at room temperature for a few minutes. After fading the color of I2, the beige suspension was added H2O (5.0 mg, 0.28 mmol) followed by the solution of 2-octanone (11) (12 mg, 0.093 mmol) in dry t-BuOH (0.46 mL) dropwise during 10 min. After the reaction mixture was stirred at room temperature for additional 1 h, the mixture was concentrated in vacuo. The residue was dissolved in water and washed with dichloromethane three times. HCl-acidified aqueous phase was extracted with dichloromethane two times and then with diethyl ether. The combined organic phase was washed with aqueous Na2S2O3 solution and brine, dried over Na2SO4, filtered, and concentrated under an aspiratory vacuum to give heptanoic acid (12) (12 mg) as an oil (93% purity, confirmed by 1H NMR). The residue was dissolved in DMF (2.0 mL) and added K2CO3 (13.8 mg, 0.1 mmol), benzyl bromide (18 mg. 0.1 mmol), and 18-crown-6 (8.0 mg, 0.030 mmol). After heating the solution at 85 °C for 24 h, the mixture was concentrated in vacuo and purified by silica gel column chromatography (hexane:toluene = 1:1) to give benzyl heptanoate (7.2 mg) as a pale yellow oil:51 IR (neat): ν = 2958, 2928, 2857, 1737, 1455, 1376, 1216, 1160, 1102, 1003, 733, 696, 527 cm−1; 1H NMR (500 MHz, CDCl3): δ = 7.40–7.30 (m, 5 H), 5.11 (s, 2 H), 2.35 (t, J = 7.5 Hz, 2 H), 1.64 (quint, J = 7.5 Hz, 2 H), 1.36–1.24 (m, 6 H), 0.87 ppm (t, J = 7.0 Hz, 3 H); 13C NMR (125 MHz, CDCl3): δ = 173.7, 136.2, 128.5, 128.17 (o, p), 66.1, 34.4, 31.4, 28.8, 24.9, 22.5, 14.0 ppm. (Fig. 6)
Products 17, 19, 23, 25, and 31 were obtained by recrystallization of residue from hexane.
General procedure for demethylation of ketone with I2 and t-BuOK in t-BuOH (in case of volatile products). A typical example: demethylation of acetylcyclopropane (25)
To a stirred solution of t-BuOK (81 mg, 0.72 mmol) in distilled t-BuOH (1.4 mL) was added I2 (69 mg, 0.27 mmol) and the mixture was stirred at room temperature for a few minutes. After fading the color of I2, the beige suspension was added H2O (4.8 mg, 0.27 mmol) and then the solution of acetylcyclopropane (25) (7.5 mg, 0.089 mmol) in dry t-BuOH (0.43 mL) dropwise during 10 min. After the reaction mixture was stirred at room temperature for additional 1 h, the mixture was concentrated in vacuo. The residue was suspended in MeCN (1.8 mL) and added benzyl bromide (17 mg, 0.097 mmol) and 18-crown-6 (3.0 mg, 0.012 mmol). After heating the solution at 75 °C for 24 h, the mixture was concentrated in an aspiratory vacuum to give an oil, which was purified by silica gel column chromatography (hexane then hexane-ethyl acetate = 1:1) to give benzyl cyclopropanecarboxylate as an oil. 1H NMR analysis (1,4-dioxane as an internal standard) showed the formation of benzyl cyclopropanecarboxylate (88%). Further purification by silica gel column chromatography (hexane:toluene = 1:1) to give benzyl cyclopropanecarboxylate (11 mg, 67%) as a pale yellow oil:52 IR (neat): ν = 3102–2750, 1725, 1455, 1397, 1360, 1265, 1164, 1065, 1029, 890, 747, 697 cm−1; 1H NMR (500 MHz, CDCl3): δ = 7.40–7.31 (m, 5 H), 5.12 (s, 2 H), 1.66 (tt, J = 7.5, 4.5 Hz, 1 H), 1.03 (dt, J = 7.5, 4.5 Hz, 2 H), 0.87 ppm (td, J = 7.5, 4.5 Hz, 2 H); 13C NMR (125 MHz, CDCl3): δ = 174.8, 136.2, 128.6, 128.2 (3 C), 66.3, 12.9, 8.6 ppm; MS: m/z (%): 176 (30) (M +), 104 (18), 91 (100), 77 (32), 69 (56), 65 (31), 51 (16) (Fig. 6).
Tandem oxidation–demethylation of 2-decanol (31) with I2 and t-BuOK in t-BuOH
To a stirred solution of t-BuOK (106 mg, 0.94 mmol) in distilled t-BuOH (1.4 mL) was added I2 (96 mg, 0.38 mmol) and the mixture was stirred at room temperature for a few minutes. After fading the color of I2, the beige suspension was added H2O (5.0 mg, 0.28 mmol) and then the solution of 2-decanol (31) (15 mg, 0.093 mmol) in dry t-BuOH (0.46 mL) dropwise during 10 min. After the reaction mixture was stirred at room temperature for additional 3 h, the mixture was concentrated in vacuo. The residue was dissolved in water and washed with dichloromethane three times. HCl–acidified aqueous phase was treated with excess Na2S2O3, and extracted with dichloromethane two times and then with diethyl ether. The combined organic phase was washed with brine, dried over Na2SO4, filtered, and concentrated under an aspiratory vacuum to give nonanoic acid (32) (16 mg) as an oil (71% purity, confirmed by 1H NMR). Further purification by silica gel column chromatography (hexane:toluene = 1:1) after benzylation using above-mentioned procedure for 12 gave pure benzyl nonanoate (1.5 mg) as a pale yellow oil53: IR (neat): ν = 2954, 2925, 2855, 1736, 1456, 1156, 1108, 734, 696 cm−1; 1H NMR (500 MHz, CDCl3) δ 7.40–7.30 (m, 5 H), 5.11 (s, 2 H), 2.35 (t, J = 7.5 Hz, 2 H), 1.64 (quint, J = 7.5 Hz, 2 H), 1.35–1.20 (m, 10 H), 0.87 ppm (t, J = 7.5 Hz, 3 H); 13C NMR (125 MHz, CDCl3): δ = 173.7, 136.2, 128.5, 128.2 (3 C), 66.1, 34.4, 31.8, 29.2, 29.14, 29.12, 25.0, 22.6, 14.1 ppm; MS: m/z (%): 248 (2) (M +), 108 (33), 91 (100), 77 (10), 65 (15) (Fig. 6).
References
Pileidis, F. D. & Titirici, M.-M. Levulinic Acid Biorefineries: New Challenges for Efficient Utilization of Biomass. ChemSusChem 9, 562–582 (2016).
Mukherjee, A., Dumont, M.-J. & Raghauan, V. Sustainable Production of Hydroxymethylfurfural and Levulinic Acid: Challenges and Opportunities. Biomass and Bioenergy 72, 143–183 (2015).
Isikgor, F. H. & Remzi Becer, C. Lignocellulosic biomass: a sustainable platform for the production of bio-based chemicals and polymers. Polym. Chem 6, 4497–4559 (2015).
Climent, M. J., Corma, A. & Iborra, S. Conversion of biomass platform molecules into fuel additives and liquid hydrocarbon fuels. Green Chem. 16, 516–547 (2014).
Deuss, P. J., Barta, K. & de Vries, J. G. Homogeneous catalysis for the conversion of biomass and biomass-derived platform chemicals. Catal. Sci. Technol 4, 1174–1196 (2014).
Dutta, S. & Pal, S. Promises in direct conversion of cellulose and lignocellulosic biomass to chemicals and fuels: Combined solvent–nanocatalysis approach for biorefinary. Biomass and Bioenergy 62, 182–197 (2014).
Cok, B., Tsiropoulos, I., Roes, A. L. & Patel, M. K. Succinic acid production derived from carbohydrates: An energy and greenhouse gas assessment of a platform chemical toward a bio-based economy. Biofuel. Bioprod. Bior. 8, 16–29 (2014).
Deng, W., Zhang, Q. & Wang, Y. Catalytic transformations of cellulose and cellulose-derived carbohydrates into organic acids. Catalysis Today 234, 31–41 (2014).
Kobayashi, H. & Fukuoka, A. Synthesis and utilisation of sugar compounds derived from lignocellulosic biomass. Green Chem. 15, 1740–1763 (2013).
Nemoto, K., Tominaga, K. & Sato, K. Facile and Efficient Transformation of Lignocellulose into Levulinic Acid Using an AlCl3·6H2O/H3PO4 Hybrid Acid Catalyst. Bull. Chem. Soc. Jpn 88, 1752–1754 (2015).
Nemoto, K., Tominaga, K. & Sato, K. Straightforward Synthesis of Levulinic Acid Ester from Lignocellulosic Biomass Resources. Chem. Lett. 43, 1327–1329 (2014).
Tominaga, K., Mori, A., Fukushima, Y., Shimada, S. & Sato, K. Mixed-acid systems for the catalytic synthesis of methyl levulinate from cellulose. Green Chem. 13, 810–812 (2011).
Other groups have also reported methods for conversion of cellulose to levulinic acid, albeit in moderate yields (See references 13 and 14).
Joshi, S. S., Zodge, A. D., Pandare, K. V. & Kulkarni, B. D. Efficient Conversion of Cellulose to Levulinic Acid by Hydrothermal Treatment Using Zirconium Dioxide as a Recyclable Solid Acid Catalyst. Ind. Eng. Chem. Res. 53, 18796–18805 (2014).
Weingarten, R., Conner, W. C. & Huber. G. W. Production of levulinic acid from cellulose by hydrothermal decomposition combined with aqueous phase dehydration with a solid acid catalyst. Energy Environ. Sci. 5, 7559–7574 (2012), and references therein.
Werpy, T. et al. Top value added chemicals from biomass. Volume 1-Results of screening for potential candidates from sugars and synthesis gas. (DTIC Document, 2004)
McKinlay, J. B., Vielle, C. & Zeikus, J. G. Prospects for a bio-based succinate industry. Appl. Microbiol. Biotechnol. 76, 727–740 (2007).
Bechthold, I., Bretz, K., Kabasci, S., Kopitzky, R. & Springer, Succinic Acid: A New Platform Chemical for Biobased Polymers from Renewable Resources. A. Chem. Eng. Technol. 31, 647–654 (2008).
Multi-step transformations of 1 to 2, see: Motoki, S. Synthetic Studies Starting from Levulinic Acid. VI. Syntheses of α-Ketoglutaric Acid, Succinic Semialdehyde and Glutamic Acid. Nippon Kagaku Zasshi 82, 740–743 (1961).
Ozonolytic cleavage of δ-benzylidene levulinic acid, readily prepared from levulinic acid and benzaldehyde, to form 2-oxoglutaric acid, see: Mitschka, R. et al. General approach for the synthesis of polyquinanes. Facile generation of molecular complexity via reaction of 1,2-dicarbonyl compounds with dimethyl 3-ketoglutarate. Tetrahedron 37, 4521–4542 (1981).
Oxidative decarbonylation of 2-oxoglutaric acid to yield succinic acid with H2O2 and Amberlyst-15, see: Choudhary, H., Nishimura, S. & Ebitani, K. Metal-free oxidative synthesis of succinic acid from biomass-derived furan compounds using a solid acid catalyst with hydrogen peroxide. Appl. Cat. A: General 458, 55–62 (2013).
Dunlop, A. P. & Smith, S. Preparation of succinic acid. US Patent, 2676186 (1954).
Podolean, I. et al. Ru-based magnetic nanoparticles (MNP) for succinic acid synthesis from levulinic acid. Green Chem. 15, 3077–3082 (2013).
Pandey, S. K., Yadav, S. P. S., Prasad, M. & Prasad, J. Mechanism of Ru(III) Catalysis in Oxidation of Levulinic Acid by Acidic Solution of N-Bromobenzamide. Asian J. Chem. 11, 203–206 (1999).
Tollens, B. Ueber die Oxydation der Laevulinsäure. Chem. Ber. 12, 334–338 (1879).
Caretto, A. & Perosa, A. Upgrading of Levulinic Acid with Dimethylcarbonate as Solvent/Reagent. ACS Sustainable Chem. Eng. 1, 989–994 (2013).
Winnik, M. A. & Stoute, V. Steric Effects in the Baeyer–Villiger Reaction of Simple Ketones. Can. J. Chem. 51, 2788–2793 (1973).
Krow, G. R. The Baeyer-Villiger Oxidation of Ketones and Aldehydes. Org. React. 43, 251–798 (1993).
Dutta, S., Wu, L. & Mascal, M. Efficient, metal-free production of succinic acid by oxidation of biomass-derived levulinic acid with hydrogen peroxide. Green Chem. 17, 2335–2338 (2015).
Only limited success in haloform reaction of aliphatic ketones with internal C–H bonds has been reported (see references 31–34).
Kajigaeshi, S., Nakagawa, T., Nagasaki, N. & Fujisaki, S. An Efficient Variant of the Haloform Reaction using Sodium Bromite. Synthesis, 674–675 (1985).
Wallach, O. Zur Kenntnis der Terpene und der ätherischen Öle. Über die Abwandlung von Trimethyläthylen in Trimethylcyclopentenon. Justus Liebigs Ann. Chem. 408, 183–202 (1915).
Borsche, W. Über δ-Phenyl-valeryl-ketone und δ-Phenyl-valeriansäure. Ber. Deutsch. Chem. Ges. 44, 2594–2596 (1911).
Fuson, R. C. & Bull, B. A. The Haloform Reaction. Chem. Rev. 15, 275–309 (1934).
Both 2-hydroxysuccinic acid (malic acid) 4 and fumaric acid 5 are also among the top 12 valuable building blocks (four-carbon 1,4-diacids) derived from biomass according to the United States Department of Energy (U.S. DOE). See also reference 15.
Mori, N. & Togo, H. Facile oxidative conversion of alcohols to esters using molecular iodine. Tetrahedron 61, 5915–5925 (2005).
Tammer, D. D., Gildley, G. C., Das, N., Rowe, J. E. & Potter, A. On the structure of tert-butyl hypoiodite. J. Am. Chem. Soc. 106, 5261–5267 (1984).
Barton, D. H. R., Beckwith, J. & Goosen, A. Photochemical transformations. Part XVI. A novel synthesis of lactones. J. Chem. Soc. 181–190 (1965).
Takeda, Y., Okumura, S. & Minakata, S. Oxidative Dimerization of Aromatic Amines using tBuOI: Entry to Unsymmetric Aromatic Azo Compounds. Angew. Chem. Int. Ed. 51, 7804–7808 (2012).
Minakata, S., Sasaki, I. & Ide, T. Atmospheric CO2 Fixation by Unsaturated Alcohols Using tBuOI under Neutral Conditions. Angew. Chem. Int. Ed. 49, 1309–1311 (2010).
t-BuOI does not disproportionate to inactive IO3 − and I−, which is sometimes observed when I2 is used in alkaline aqueous solution. Haimovich, O. & Treinin, A. Disproportionation of hypoiodite. J. Phys. Chem. 71, 1941–1943 (1967).
Kende, A. S. Org. React. 11, 261–316 (1960).
Bergmann, E. D., Rabinovitz, M. & Levinson, Z. H. The Synthesis and Biological Availability of Some Lower Homologs of Cholesterol. J. Am. Chem. Soc. 81, 1239–1243 (1959).
Hirayama, Y. et al. Stereochemical Assignment of C-24 and C-25 of Amarasterone A, a Putative Biosynthetic Intermediate of Cyasterone. J. Org. Chem. 79, 5471–5477 (2014).
Carmen de la Fuente, M. & Dominguez, D. Normal electron demand Diels–Alder cycloaddition of indoles to 2,3-dimethyl-1,3-butadiene. Tetrahedron 67, 3997–4001 (2011).
Min, K. L., Steghens, J. P., Henry, R., Doutheau, A. & Collombel, C. Synthesis and differential properties of creatine analogues as inhibitors for human creatine kinase isoenzymes. Eur. J. Biochem. 238, 446–452 (1996).
Thomas, A. F. & Waillhalm, B. Les spectres de masse dans l’ analyse les transferts d’hygrogène dans des cétones norbornyliques. Helv. Chim. Acta 50, 826–840 (1967).
Sawatzki, P. & Kolter, T. Syntheses of 3-C-Methylceramides. Eur. J. Org. Chem. 3693–3700 (2004).
Nilsson, M. et al. High-Resolution NMR and Diffusion-Ordered Spectroscopy of Port Wine. J. Agric. Food Chem. 52, 3736–3743 (2004).
Sakakura, A., Ohkubo, T., Yamashita, R., Akakura, M. & Ishihara, K. Brønsted Base-Assisted Boronic Acid Catalysis for the Dehydrative Intramolecular Condensation of Dicarboxylic Acids. Org. Lett. 13, 892–895 (2011).
Hirano, K., Yorimitsu, H. & Oshima, K. Nickel-Catalyzed 1,4-Addition of Trialkylboranes to α,β-Unsaturated Esters: Dramatic Enhancement by Addition of Methanol. Org. Lett. 9, 1541–1544 (2007).
Tummatorn, J., Albiniak, P. A. & Dudley, G. B. Synthesis of Benzyl Esters Using 2-Benzyloxy-1-methylpyridinium Triflate. J. Org. Chem. 72, 8962–8964 (2007).
Profir, I., Beller, M. & Fleischer, I. Novel ruthenium-catalyst for hydroesterification of olefins with formats. Org. Biomol. Chem. 12, 6972–6976 (2014).
Acknowledgements
This work was supported by JSPS KAKENHI (S) (No. 24229011) (to M.U.) and JSPS KAKENHI (C) (No. 25460016) (to K.M.). This research was also partly supported by grants (to M.U.) from Asahi Glass Foundation, Nagase Science Technology Development Foundation, Yamada Science Foundation, and Sumitomo Foundation.
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K.M. and M.U. designed and supervised the research as well as wrote the manuscript. R.K. carried out the optimization of the reaction and investigated the scope and limitations, and measured spectra of products. S.N. established one-pot synthesis of succinic acid from cellulose and investigated the scope and limitations of the reaction. K.T. and R.T. contributed to write the manuscript and revision.
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Kawasumi, R., Narita, S., Miyamoto, K. et al. One-step Conversion of Levulinic Acid to Succinic Acid Using I2/t-BuOK System: The Iodoform Reaction Revisited. Sci Rep 7, 17967 (2017). https://doi.org/10.1038/s41598-017-17116-4
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DOI: https://doi.org/10.1038/s41598-017-17116-4
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