Abstract
The electronpositron annihilation into two photons is a standard technology in medicine to observe e.g. metabolic processes in human bodies. A new tomograph will provide the possibility to observe not only direct e ^{+} e ^{−} annihilations but also the 3 photons from the decay of orthopositronium atoms formed in the body. We show in this contribution that the threephoton state with respect to polarisation degrees of freedom depends on the angles between the photons and exhibits various specific entanglement features. In particular genuine multipartite entanglement, a type of entanglement involving all degrees of freedom, is subsistent if the positronium was in a definite spin eigenstate. Remarkably, when all spin eigenstates are mixed equally, entanglement –and even stronger genuine multipartite entanglement– survives. Due to a “symmetrization” process, however, Dicketype or Wtype entanglement remains whereas GHZtype entanglement vanishes. The survival of particular entanglement properties in the mixing scenario may make it possible to extract quantum information in the form of distinct entanglement features, e.g., from metabolic processes in human bodies.
Introduction
The detection of the two high energetic photons resulting from the annihilation of an electron and a positron is a wellestablished successful technology to image metabolic processes in living bodies (PET: Positron Emission Tomography). PET application is used in many different fields of medicine, e.g. oncology, cardiology, radiation therapy or neurology. In recent years, PET instrumentation has undergone a steady multifaceted evolution and the improvements include new hardware, new reconstruction methods and implementation of timeofflight techniques^{1,2,3,4,5,6,7}. Without doubt PET serves as an important tool in imaging metabolic processes based on the sensitivity to tracers (positronemitting radionuclides) injected into the body or tissue.
Electronpositron annihilations may occur either directly or via the creation of positronium atoms (a bound state of an electron and positron). Positronium^{8,9,10,11} can be in an antisymmetric spin state (parapositronium) or a symmetric spin state (orthopositronium). Charge conjugation implies that in the first case it decays into an even number of photons (2γ, 4γ, …) and in the other case into an odd number of photons (3γ, 5γ, …). Due to kinematics and smallness of the finestructure constant the 2γ and 3γ cases are the two most likely options. During routine PET imaging, positronium atoms are formed copiously inside the human body and therefore 3γdecays occur also frequently. Even in water the production of orthopositronium has a probability equal to about 25%^{12} and is expected to be more than 38% in tissue^{13}. Threephoton events, however, have never been used in tomography because of technical limitations of standard PET devices. A new prototype, called JPET (JagiellonianPET)^{14,15,16,17,18,19}, has been shown to meet all technical requirements in performing such a measurement for the first time.
This paper investigates the entanglement in the polarisation degrees of freedom of the three photons resulting from the decay of the orthopositronium. Both for a fixed spin quantization direction of the positronium as well as the case of equal mixing. Photons are fascinating quantum systems, having spin one, but due to their massless property there is a nontrivial coupling between the spin and momentum properties. The most appropriate singlephoton description remains controversial. A recent framework describing all singlephoton states and singlephoton observables by POVMs (positiveoperator valued measurements) can be found in ref.^{20}. In this contribution we restrict ourselves to the polarisation degrees of freedom and are interested in the correlation of three photons with energies that ranges from 0 to 511 keV. Entanglement and in particular multipartite entanglement is a highly investigated field that has the potential to become a new technology. This paper makes a step towards investigating what type of entanglement is present in the threephoton state generated by the decay of orthopositronium. This may one day result in obtaining not only local information, namely where in a tissue the positronium decayed, but also revealing quantum information which may serve as a new quantum marker for specific biological processes.
Note that entanglement seems to play an important role in biological systems as e.g. observed in the light harvesting complexes, e.g. ref.^{21}, in bird navigation (European robin)^{22,23} or in olfaction^{24}. Let us emphasize here that these works have led to a paradigm change in the sense that life may be too “warm and wet” for quantum phenomena to endure.
The paper is organized as follows. First we introduce the 3photon state resulting from the decay of orthopositronium. Then we analyse the multipartite entanglement of the pure state scenario including a discussion of the distribution of entanglement among the three photons. Then we proceed to the mixed scenario proving that entanglement is not lost. This is followed by a summary and outlook.
The states relevant in orthopositronium decays
Orthopositronium decays mainly into 3 photons. The resulting state of the 3 photons depends on the quantization direction \(\hat{\overrightarrow{n}}\) of the orthopositronium’s spin state (total spin 1). If the third component \({s}_{\hat{\overrightarrow{n}}}\) is zero, the state is given by
with the normalisation
and the polarisation operator
and the state
written in the computational basis {0〉, 1〉} which is defined as the eigenstates with respect to the internal frame of each photon and may be identified with the linear polarised states H〉, V〉. The states ϕ ^{±}〉 = 00〉 ± 11〉, ψ ^{±}〉 = 01〉 ± 10〉 are the Bell states (not normalized). The states +/−〉 correspond to the right/lefthanded circular polarised photons with respect to the choice of internal space of each photon \(+/\rangle =\frac{1}{\sqrt{2}}\{0\rangle \pm i1\rangle \}\). Assuming that a particular photon i travels in the zdirection, then 0〉, 1〉 can be identified also with the electric field components in the x,ydirection, respectively. This state Ψ〉_{ abc } is also known to be a GreenbergerHornZeilinger (GHZ) state (discussed later).
Due to momentum and energy conservation the three momenta of the photons have to lie in a plane, which will be denoted as the decay plane. The operator \({\hat{ {\mathcal R} }}_{pol}({\tilde{{\rm{\Theta }}}}_{ab},\,{\tilde{{\rm{\Theta }}}}_{bc})\) covers the symmetries superposed by the decay process on the polarisation degrees of freedom, where \({\tilde{{\rm{\Theta }}}}_{ij}\) corresponds to the angles between photon i and j, that all lie in the decay plane (see Fig. 1). Further restrictions due to momentum and energy conservation on these angles are discussed at the end of this section.
The phase \({{\rm{\Phi }}}_{plane}\in [0,\,\frac{\pi }{2})\) is the angle between the spinquantization direction \(\hat{\overrightarrow{n}}\) of the orthopositronium and the decay plane formed by the three photons’ momenta. Therefore, the other two possible eigenstates of orthopositronium \({s}_{\hat{\overrightarrow{n}}}=\pm 1\) are obtained by three local rotations, i.e.
A detailed computation of the state \({{\rm{\Psi }}}_{{s}_{\hat{\overrightarrow{n}}}}\rangle \) based on quantum electrodynamic (QED) for the case Φ_{ plane } = 0 can be found in ref.^{25}.
Momentum and energy conservation constrains also the allowed values of the angles \({\tilde{{\rm{\Theta }}}}_{ab},{\tilde{{\rm{\Theta }}}}_{bc}\) of the three momenta forming the decay plane. Energy conservation in the rest mass system of the positronium leads to (\(\hslash c\equiv 1\))
which fixes one energy value of the three photons. Momentum conservation relates the values of energy of any two photons a, b to its solid angle by
A solution is only obtained if the function on the righthand side is in the interval [−1, 1]. The lower bound −1 implies that a single photon can have at most half of the total energy E, and the upper bound +1 bounds the sum of both energies to half of the total energy E. The possible range of angles is shown in Fig. 2. The kinematics thus singles out the region denoted by (I). In summary, the full parameter space is not physically attainable due to energy and momentum conservation.
Results
Entanglement properties of the pure 3photonstates
In the following we want to consider the polarisation degrees of freedom of the threephoton state, independent of the kinematical constraints. From this perspective the states \({{\rm{\Psi }}}_{{s}_{\hat{\overrightarrow{n}}}}\rangle \) are tripartite qubit systems (qubit... twolevel systems).
Any entanglement of a tripartite state can be classified according to the kseparability^{26} (for a more recent overview of the subtleties concerning the classification of multipartite states see e.g. ref.^{27}). If a pure npartite state can be written in the form
with k ≤ n, it is called for k = n fully separable, for 1 < k < n partially separable (kseparable) or for k = 1 fully entangled (1separable). There is a straightforward extension to mixed states, i.e., if a mixed state can be written as a convex combination of at least kseparable states, i.e. (p _{ i } ≥ 0)
with k ≤ n, it is classified as in the case for pure states. Note that 1separable states are also called genuinely multipartite entangled states and these states are the most interesting ones with respect to outperforming algorithms exploiting classical physics.
This classification is certainly not fine enough. Already for the simplest case, three qubits, we have two physically very different subclasses of 1separable states or genuinely multipartite entangled states: The GHZstates (GHZ... Greenberger, Horne, Zeilinger)
and the Dicke states (W states called in the case of three qubits), e.g.,
Both are obviously a particular generalization of the maximally entangled Bell states, but their physical properties are very different. For example, if one subsystem is traced out, the entanglement is fully lost in the case of GHZtype entanglement, in contrast to the Wtype entanglement, where the subsystems are entangled. It has been shown that the GHZtype entanglement can be utilized for multipartite quantum cryptography^{28,29,30} whereas for Dicketype entanglement no such schemes have been found that outperform bipartite entangled systems. Dicketype entanglement is often present in condensed matter systems^{31} or is produced by a double down conversion process resulting in four genuinely multipartite entangled photons^{32,33}. For single neutrons in an interferometric setup, three degrees of freedom can be engineered, i.e. spin, path and energy, for which both types of genuine multipartite entanglement have been generated experimentally^{34}. Recently, also atoms in a solid have been proven to be genuinely multipartite entangled^{35,36}. Topological and nematic phase transitions in spin chains are shown to be ruled by genuine multipartite entanglement^{37,38,39}, even if bipartite entanglement dies out^{40}.
Our first aim is to analyze the entanglement of the three photons resulting from the orthopositronium decay. Without loss of generality we can set Φ_{ plane } = 0 and \({s}_{\hat{\overrightarrow{n}}}=0\) since the entanglement properties do not depend on local unitaries (if not mixed). Thus the state under investigation depends only on the two azimuth angles
For pure states, wellestablished bipartite entanglement criteria serve the purpose of revealing all the entanglement. For mixed states, since entanglement detection is a NPhard problem^{41}, only necessary but not sufficient criteria can be found. The HMGHframework^{42} provides such necessary criteria to classify the different types of multipartite entanglement. This framework connects local observables, density matrix elements, to distinct types of entanglement and is therefore also experimentally feasible.
In ref.^{42} it was proven that the following criterion holds for all kseparable states ρ
where χ〉 = χ _{1}〉⊗χ _{2}〉 is an arbitrary fully separable state, \({P}_{{\alpha }_{i}}\) is a permutation operator permuting the α _{ i }th elements of χ _{1}〉 and χ _{2}〉 and the sum runs over all kpartitions {α}. And the total permutation acts as P _{ total }χ _{1}〉⊗χ _{2}〉 = χ _{2}〉⊗χ _{1}〉. Obviously, if this inequality is violated the state ρ cannot be kseparable. Note that the reverse argument does not hold since a nonviolation does not necessarily imply kseparability. Consequently, these criteria are necessary but not sufficient criteria for kseparability. Since the above criteria obviously depend on the choice of the fully separable state χ〉 and the chosen basis of ρ, one always has to optimize over local unitaries in order to obtain the optimum (which is performed in all the following computations).
For three qubits a value of Q _{ k=3}(ρ) greater than zero detects entanglement of ρ and a value of Q _{ k=2}(ρ) greater than zero detects the state to be genuinely multipartite entangled. It also turns out that Q _{ k=2}(ρ) is the one that gives the highest value for the GHZstate, i.e. Q _{ k=2}(GHZ〉) = 1. In strong contrast to the W states which give Q _{ k=2}(W〉) = 0.629. In the following we therefore denote this criterion by Q _{ GHZ } := Q _{ k=2}. And by Q _{ SEP } := Q _{ k=3} the criterion detecting entanglement but not necessarily genuine multipartite entanglement. Explicitly, we can rewrite the criteria which detects entanglement if the value is greater than zero by
The criterion, which detects genuine multipartite entanglement if the value is greater than zero and is maximized for any GHZstate, can be rewritten as
This formulation reveals the very working of the criteria, i.e. that the only offdiagonal elements of these criteria are exactly the only nonzero offdiagonal element of the GHZstate, and the negative terms are the diagonal elements of ρ which are all zero in the case of the GHZstate.
A criterion to optimize for the Wtype entanglement can also be derived via the HMGHframework^{42}. The same strategy as above can be used, i.e. choosing the nonzero elements of the Wstate, i.e. 001〉, 010〉 or 100〉 for the fully separable state χ _{1}〉 and χ _{2}〉. Since we have now three combinations we can add these three inequalities to have a symmetric criterion. In ref.^{43}, however, it was shown that one can obtain a stricter inequality if one adds a further constraint coming from the positivity condition. For 3particles with two degrees of freedoms the following criterion detects genuine multipartite entanglement if greater than zero and attains its maximal value for the Wstate
The positive terms are the only nonzero offdiagonal terms of the Wstate whereas the negative terms are the only diagonal terms that are zero in the case of the Wstate. Therefore, this criterion gives the maximum value for the Wstate. This is in strong contrast to GHZstates which obtain the value \({Q}_{W}(GHZ\rangle )=\frac{3}{4}\). The separability criterion for both genuinely multipartite entangled states is Q _{ SEP }(GHZ〉) = 1 and Q _{ SEP }(W〉) = 0.62. A summary–including the positronium case–can be found in Table 1.
Obviously these criteria are measurable by local observables since they depend only on density matrix elements, for example
where σ _{ i } are the Pauli matrices. This makes the criteria very experimenter friendly since they are attainable by local measurements only and do not need state tomography.
Deriving Q _{ SEP } for the threephoton state we find \({Q}_{SEP}({\psi }_{pure}({\tilde{{\rm{\Theta }}}}_{ab},{\tilde{{\rm{\Theta }}}}_{bc})\rangle )\ge \frac{1}{2}\), i.e. a positive value for all possible angles. Thus proving that the threephoton states resulting from the decay of positronium are always entangled. The maximum is equal to 0.89 and is reached for \({\tilde{{\rm{\Theta }}}}_{ab}=\frac{\pi }{16},\,{\tilde{{\rm{\Theta }}}}_{bc}=\frac{\pi }{16}\) in the nonphysical area. The contour plot in Fig. 3(a) shows the details. Whereas the threephoton state is entangled for all possible decay configurations \(\{{\tilde{{\rm{\Theta }}}}_{ab},\,{\tilde{{\rm{\Theta }}}}_{bc}\}\), this surprisingly holds true also for genuine multipartite entanglement detected by Q _{ GHZ } or by Q _{ W }. Both criteria differ only in the amount of the violation of the inequality, see Fig. 3(b) and (c).
Summarizing, neglecting the kinematical constraints onto the polarisation degrees of freedom, described mathematically by \({R}_{pol}({\tilde{{\rm{\Theta }}}}_{ab},\,{\tilde{{\rm{\Theta }}}}_{bc})\), the resulting threephoton state in the decay process of the positronium would be a pure GHZstate, a maximal entangled threequbit state. The superimposed constraints result in a dependence of entanglement on the decay angles obeying the indistinguishability of the individual photons.
In the next section we analyse the distribution of the bipartite entanglement between the individual photons, which will answer how these kinematical constraints onto the polarisation degrees of freedom concentrates different types of genuine multipartite entanglement.
Entanglement of the reduced system
Now we want to investigate how the entanglement is distributed among the individual photons a, b and c. From equation (4) it is obvious that without the operator \({\hat{ {\mathcal R} }}_{pol}({\tilde{{\rm{\Theta }}}}_{ab},\,{\tilde{{\rm{\Theta }}}}_{bc})\) the reduced state is an equal mixture of two Bell states which is a separable state. The kinematic operator weights not the two Bell states separately but each contribution individually. From this the invariance under permutation of the photons is lost, i.e. the three reduced states ρ _{ ab }, ρ _{ ac }, ρ _{ bc } differ as well as the entanglement content measured by concurrence. Concurrence is an analytically computable entanglement measure for qubitqubit entanglement. For pure states it simplifies to \(C(\psi \rangle )=\sqrt{\mathrm{2(1}Tr({\rho }_{i}))}\) where ρ _{ i } is the partial trace of ψ〉 with respect to the subsystem i. For a mixed state concurrence is defined by the convex roof, i.e.
For bipartite qubits it has been shown that the convex sum equals the value obtained by computing the eigenvalues of \(\sqrt{Tr(\rho {{\rm{\sigma }}}_{2}\otimes {{\rm{\sigma }}}_{2}{\rho }^{\ast }{{\rm{\sigma }}}_{2}\otimes {{\rm{\sigma }}}_{2})}\) and taking the maximal eigenvalue minus the remaining ones.
Since our total threequbit system is a pure state we can directly answer the question of how much bipartite entanglement photon a shares with photon b and photon c. Obviously, if photons b and c are in a maximal entangled state they have to be separable from photon a. Therefore, the entanglement a can share with bc limits the entanglement of bc. This can be quantified with the help of the famous CoffmanKonduWootters tangle τ _{ abc } ^{44}, i.e.
For the GHZstate the reduced states are separable states thus the concurrence is zero, whereas the tangle is maximal. The difference between the righthand side and the lefthand side is maximal. In the case of Wstates the reduced states have a value of \(C=\frac{2}{3}\) and the tangle equals \(\tau =\frac{8}{9}\), i.e. the difference is zero. Thus entanglement is distributed also among the subsystems in the case of a Wstate, whereas for GHZstates no entanglement can be found in the subsystems. Thus the tangle minus the two concurrences quantifies the difference between genuine multipartite entanglement of the GHZtype entanglement and the Wtype entanglement.
Let us note here, however, another subtle point of multipartite entanglement. Obviously, if a GHZstate as given in equation (4) is considered, a measurement of one photon in the circular polarized basis ({ + 〉,  − 〉}) leads to a separable state for the two remaining photons, i.e. ++〉 or −−〉. If the photon is instead measured in the linear polarized basis ({0〉, 1〉}) the remaining two photons have the result “0” in the Bell state ϕ ^{−}〉 or the outcome “1” in the Bell state ψ ^{+}〉, i.e. clearly maximally entangled. This perfect correlation between the polarization state of one photon and the entangled state of the two photons implies, under the EinsteinPodolskyRosen premises of realism and no action at a distance, that the entangled state of the two photons must represent an element of reality. Whereas the individual photons, which have no welldefined properties, do not correspond to such elements. For a realist this is a surprising feature. In the first scenario the two photons contain individually an element of reality, which is more satisfactory for a realist. Thus by the specific kind of measurement, projecting on linearly or circularly polarized photons, the properties of the two photons and their reality content is switched between entanglement and separability. This can also be understood from the fact that a particular factorisation per se is not favoured over another one; no partition has ontologically a superior status over any other one, therefore there is perfect democracy. However, a measurement or a physical process makes a choice.
Thus let us come back to the 3photon decay resulting from orthopositronium. Though the individual concurrences for a given setup \(({\tilde{{\rm{\Theta }}}}_{ab},\,{\tilde{{\rm{\Theta }}}}_{bc})\) differ, the difference of the tangle minus the two squared concurrences, τ _{ ijk } − C(ρ _{ ij })^{2} − C(ρ _{ ij })^{2}, has to be equal for all possible permutations of the three photons. This allows the following interpretation: The kinematics of the decay process are such that the individual bipartite entanglement can vary, however, the total amount of entanglement is not allowed to depend on these individual choices. Choosing a larger or smaller amount of bipartite entanglement of a particular pair affects the amount of entanglement of the other two bipartitions obeying a conservation of the total amount of entanglement.
The largest difference between the individual bipartite entanglement and the one shared with both remaining photons overlaps with the regions for which genuine multipartite entanglement maximizes, showing that the Wtype entanglement is more resistant against the specific setup (angles) respecting the indistinguishability of the photons. The details are plotted in Fig. 4.
Note that a decaying system can be viewed as an open quantum process^{45}, i.e. an interaction with an environment is modelled by particular operators resulting in a nonunitary evolution of the system of interest. This gives another perspective of the physics behind the decay.
Entanglement properties of the mixed 3photonstates
In case spin is not a proper quantum number, all three possible spin eigenstates \({s}_{\hat{\overrightarrow{n}}}=0,\,+1,\,1\) are equally probable, then the resulting state is
with \(p=\frac{1}{3}\). Computing the mixedness Trρ ^{2} we find for \(p=1,\,\frac{1}{3}\) no dependence on Φ_{ plane }. This is also the case for the entanglement properties of the state, thus without loss of generality we can set Φ_{ plane } = 0.
The three criteria Q _{ SEP }, Q _{ GHZ } and Q _{ W } are presented in Fig. 5. Remarkably, entanglement is not lost for any setup, however, genuine multipartite entanglement is more sensitive to the angles. Concerning the physical attainable region we find that Q _{ SEP } attains in good approximation a constant value (Q _{ SEP } = [0.17, 0.2]) which shows a kind of symmetrization in the sense that the difference between the relevant off diagonal element and the sum of the relevant diagonal elements of the density matrix is constant, see equation (14), however, it is strictly nonpositive for Q _{ GHZ }. In strong contrast, Q _{ W } reveals differences in the entanglement properties since it still varies strongly with the angles. Consequently, this criterion reveals refined properties of the system under investigation. This proves that entanglement properties of the state can be revealed in the highly mixed scenario and gives the hope that biological properties of the system may be obtainable.
In summary, GHZtype entanglement can no longer be found in a physically available region, however, Wtype entanglement is robust against this mixing. Particularly, in the fully symmetric case \({\tilde{{\rm{\Theta }}}}_{ab}={\tilde{{\rm{\Theta }}}}_{bc}=\frac{2\pi }{3}\) we find a local maximum with the value Q _{ W } = 0.5. This shows that the dynamics of the decay process does not wash out fully the entanglement features and favours Dicketype entanglement over GHZtype entanglement. Thus the decay process favours a symmetrization among the three photons enabling bipartite entanglement. From the theoretical point of view different classes of multipartite entangled states cannot be converted into each other by local operations and classical communication (LOCC), only nonlocal operations could do the job. The mixing can thus be seen as a procedure resulting in a state where tracing out one photon does not lead to a separable state, i.e. transforming to a certain type of genuinely multipartite entangled state maximizing bipartite entanglement, i.e. a Wtype state (defined as being detected by Q _{ W } but not Q _{ GHZ }). The process is most symmetric for a spatial symmetric state (\({\tilde{{\rm{\Theta }}}}_{ab}={\tilde{{\rm{\Theta }}}}_{bc}=\frac{2\pi }{3}\)). Thus the spatial symmetry of the three momenta superposes the symmetry of the polarisation degrees of freedom which is obviously due to the close relationship between momenta and polarisation for relativistic massless particles (transversality condition).
Discussion
Monitoring metabolic processes as well as distinct physical reactions related to chemical processes are key ingredients for exploring nature and its very workings. We analyze the entanglement properties in the polarisation degrees of freedom of three photons resulting from the decay of ortho–positronium in the full parameter space. For this we use the HMGHframework which allows for entanglement detection in addition to refinements such as Wtype or more generally Dicketype entanglement versus GHZtype entanglement. The framework provides nonlinear entanglement witnesses based on local observables, i.e. it does not need full information on the state that in many cases is not attainable.
In particular, for a definite spin value of orthopositronium we find that entanglement and even stronger genuine multipartite entanglement is present for the full parameter space. Surprisingly, in the mixed scenario entanglement as well as genuine multipartite entanglement are not lost, however, only Wtype genuine multipartite entanglement is detectable. This is due to the interplay of the kinematics of the threebody particle decay and the Bosesymmetry constraining the entanglement properties to favor Wtype over GHZtype genuine multipartite entanglement. Furthermore, whereas the criterion detecting entanglement, Q _{ SEP }, is in good approximation constant over the physical relevant region, this is not the case for the specific criterion Q _{ W }, which reveals different properties in dependence of the decay angles due to a specific “symmetrisation process” as an effect of the decay process. Since the mixing does not destroy entanglement per se and genuine multipartite entanglement is shown to be still dependent on the angles, this proves that entanglement can be related to physical processes and gives the hope that entanglement will be related to real biological processes.
JPET, a PositronEmissionTomograph, relies on new technology enabling threephoton tomography^{17,18,19}. This is due to a new detector scheme based on plastic scintillators^{14}, novel digital sampling electronics^{15,16} and a development of trilaterationbased reconstruction^{19}. Consequently, JPET gives a possibility to determine the linear polarization of high energy photons via the registration of the direction of the photon before and after its Compton scattering^{16}. It allows for the measuring of correlations of photons with superior time and angular resolutions via Compton scattering. It is beyond the scope of this contribution to compute how the entanglement of the three photons can be revealed by the three Compton scattered photons, but we will tackle this problem in future work.
References
 1.
Slomka, P., Pan, T. & Germano, G. Recent Advances and Future Progress in PET Instrumentation. Semin. Nucl. Med. 46, 5 (2016).
 2.
Rausch, I. et al. Technical and instrumentational foundations of PET/MRI. European Journal of Radiology. 94, A3 (2017).
 3.
Vandenberghe, S. & Marsden, P. K. PETMRI: a review of challanges and solutions in the development of integrated multimodality imaging. Phys. Med. Biol. 60, R115 (2015).
 4.
Conti, M. Focus on timeofflight PET: the benefits of improved time resolution. Eur. J. Nucl. Med. Mol. Imaging 38, 1147 (2011).
 5.
Karp, J. S. et al. Benefit of TimeofFlight in PET: Experimental and Clinical Results. J. Nucl. Med. 49, 462 (2008).
 6.
Humm, J. L., Rosenfeld, A. & Del Guerra, A. From PET detectors to PET scanners. Eur. J. Nucl. Med. Mol. Imaging 30, 1574 (2003).
 7.
Moses, W. W. & Derenzo, S. E. Prospects for TimeofFlight PET using LSO scintillator. IEEE Trans. Nucl. Sci. 46, 474 (1999).
 8.
Deutsch, M. ThreeQuantum Decay of Positronium. Phys. Rev. 82, 455 (1951).
 9.
AlRamadhan, A. H. & Gidley, D. W. New precision measurement of the decay rate of singlet positronium. Phys. Rev. Lett. 72, 1632 (1994).
 10.
Vallery, R. S., Zitzewitz, P. W. & Gidley, D. W. Resolution of the OrthopositroniumLifetime Puzzle. Phys. Rev. Lett. 90, 203402 (2003).
 11.
Cassidy, D. B. et al. Positronium cooling in porous silica measured via Doppler spectroscopy. Phys.Rev. A 81, 012715 (2010).
 12.
Stepanov, S. V. et al. Incorporation of the Magnetic Quenching Effect into the Blob Model of Ps Formation. Finite Sized Ps in a Potential Well. Materials Science Forum 666, 109 (2011).
 13.
Harpen, M. D. Positronium: review of symmetry, conserved quantities and decay for the radiological physicist. Med. Phys. 31, 57 (2004).
 14.
Moskal, P. et al. Time resolution of the plastic scintillator strips with matrix photomultiplier readout for JPET tomography. Phys. Med. Biol. 61, 2025 (2016).
 15.
Moskal, P. et al. A novel method for the lineofresponse and timeofflight reconstruction in TOFPET detectors based on a library of synchronized model signals. Nucl. Instr. Meth. A 775, 54 (2015).
 16.
Moskal, P. et al. Potential of the JPET detector for studies of discrete symmetries in decays of positronium atom  a purely leptonic system. Acta Phys. Polon. B 47, 509 (2016).
 17.
Moskal, P., Moskal, I. & Moskal, G. Inventors; TOFPET tomograph and a method of imaging using a TOFPET tomograph, based on a probability of production and lifetime of a positronium, United States patent UNIWERSYTET JAGIELLONSKI (Krakow, PL) 20160216385, 2016 July 28.
 18.
Kaminska, D. et al. A feasibility study of orthopositronium decays measurement with the JPET scanner based on plastic scintillators. Eur. Phys. J. C 76, 445 (2016).
 19.
Gajos, A. et al. Trilaterationbased reconstruction of orthopositronium decays into three photons with the JPET detector. Nucl. Instr. and Meth. A 819, 54 (2016).
 20.
Guarnieri, G., Motta, M. & Lanz, L. Singlephoton observables and preparation uncertainty relations. J.Phys. A: Math. Theor. 46, 265302 (2015).
 21.
Sarovar, M., Ishizaki, A., Fleming, G. R. & Whaley, K. B. Quantum entanglement in photosynthetic lightharvesting complexes. Nature Physics 6, 462 (2010).
 22.
Cai, J., Guerreschi, G. G. & Briegel, H. J. Quantum Control and Entanglement in a Chemical Compass. Phys. Rev. Lett 104, 220502 (2010).
 23.
Gauger, E. M., Rieper, E., Morton, J. J. L., Benjamin, S. C. & Vedral, V. Sustained Quantum Coherence and Entanglement in the Avian Compass. Phys. Rev. Lett. 106, 040503 (2011).
 24.
Franco, M. I., Turin, L., Mershin, A. & Skoulakis, E. M. C. Molecular vibrationsensing component in Drosophila melanogaster olfaction. Proc. Natl. Acad. Sci. Am. 108, 3797 (2011).
 25.
Acin, A., Latorre, J. I. & Pascual, P. Threeparty entanglement from positronium. Phys. Rev. A 63, 042107 (2001).
 26.
Horodecki, M., Horodecki, P. & Horodecki, R. Separability of Mixed States: Necessary and Sufficient Conditions. Phys. Lett. A 223, 1 (1996).
 27.
Chruściński, D. & Sarbicki, G. Entanglement witnesses: construction, analysis and classification. J. Phys. A: Math. Theor. 47, 483001 (2014).
 28.
Schauer, S., Huber, M. & Hiesmayr, B. C. Experimentally Feasible Security Check for nqubit Quantum Secret Sharing. Phys. Rev. A 82, 062311 (2010).
 29.
Karlsson, A., Koashi, M. & Imoto, N. Quantum Entanglement for Secret Sharing and Secret Splitting. Phys. Rev. A 59, 162 (1999).
 30.
Hillery, M., Buzek, V. & Berthiaume, A. Quantum Secret Sharing. Phys. Rev. A 59, 1829 (1999).
 31.
Dicke, R. H. Coherence in Spontaneous Radiation Processes. Phys. Rev. 93, 99 (1954).
 32.
Hiesmayr, B. C., de Dood, M. J. A. & Löffler, W. Fourphoton orbital angular momentum entanglement. Phys. Rev. Lett. 116, 073601 (2016).
 33.
Krenn, M., Malik, M., Erhard, M. & Zeilinger, A. Orbital angular momentum of photons and the entanglement of LaguerreGaussian modes. Philosophical Transactions of the Royal Society A 375, 20150442 (2016).
 34.
Erdösi, D., Huber, M., Hiesmayr, B. C. & Hasegawa, Y. Proving the Generation of Genuine Multipartite Entanglement in a SingleNeutron Interferometer Experiment. New J. Phys. 15, 023033 (2013).
 35.
Fröwis, F. et al. Experimental certification of millions of genuinely entangled atoms in a solid, arXiv:1703.04704.
 36.
Zarkeshian, P. et al. Entanglement between more than two hundred macroscopic atomic ensembles in a solid, arXiv:1703.04709.
 37.
Giampaolo, S. M. & Hiesmayr, B. C. Topological and nematic ordered phases in manybody clusterIsing models. Phys. Rev. A 92, 012306 (2015).
 38.
Giampaolo, S. M. & Zonzo, G. Quench of a symmetrybroken ground state. Phys. Rev. A 95, 012121 (2017).
 39.
Lee, T. E., Joglekar, J. N. & Richerme, P. String order via Floquet interactions in atomic systems. Phys. Rev. A 94, 023610 (2017).
 40.
Zhang, Y.Y., Chen, X.Y., He, S. & Chen, Q.H. Analytical solutions and genuine multipartite entanglement of the threequbit Dicke model. Phys. Rev. A 94, 012317 (2016).
 41.
Gurvits, L. Classical complexity and quantum entanglement. Journal of Computer and System Sciences 69, 448 (2004).
 42.
Huber, M., Mintert, F., Gabriel, A. & Hiesmayr, B. C. Detection of highdimensional genuine multipartite entanglement of mixed states. Phys. Rev. Lett. 104, 210501 (2010).
 43.
Huber, M., Erker, P., Schimpf, H., Gabriel, A. & Hiesmayr, B. C. Experimentally feasible set of criteria detecting genuine multipartite entanglement in nqubit Dicke states and in higher dimensional systems. Phys. Rev. A 83, 040301(R) (2011); Phys. Rev. A 84, 039906(E) (2011).
 44.
Coffman, V., Kundo, J. & Wootters, W. K. Distributed entanglement. Phys. Rev. A 61, 052306 (2000).
 45.
Bertlmann, R. A., Grimus, W. & Hiesmayr, B. C. An open–quantum–system formulation of particle decay. Phys. Rev. A 73, 054101 (2006).
Acknowledgements
B.C.H. acknowledges gratefully the Austrian Science Fund (FWFP26783) and P.M. acknowledges support by the National Science Centre through the grant No. 2016/21/B/ST2/01222. The authors are thankful for the helpful comments and proofreading of Dan McNuthy.
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Both authors contributed equally to the computations and analyses and reviewed the manuscript.
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Correspondence to Beatrix C. Hiesmayr.
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Hiesmayr, B.C., Moskal, P. Genuine Multipartite Entanglement in the 3Photon Decay of Positronium. Sci Rep 7, 15349 (2017) doi:10.1038/s4159801715356y
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